Molecular mechanisms of copper homeostasis
Molecular mechanisms of copper homeostasis
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DOI：
10.1006/bbrc.1999.1073
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发表时间：
1999-08-02
影响因子：
3.1
通讯作者：
Mercer, JF
中科院分区：
文献类型：
--
作者：
Camakaris, J;Voskoboinik, I;Mercer, JF
铜是人体必需的微量元素，是重要的铜原酶的核心组成部分，在细胞生理中起着举足轻重的作用。最近在分子水平上发现了人类铜稳态的新成分。这些包括铜运输的p型atp酶，Menkes和Wilson蛋白，以及铜伴侣蛋白。这些发现为更好地理解铜缺乏或铜毒性在生理和病理条件下的作用铺平了道路。(C) 1999学术出版社。
Copper is an essential trace element which plays a pivotal role in cell physiology as it constitutes a core part of important cuproenzymes. Novel components of copper homeostasis in humans have been identified recently which have been characterised at the molecular level. These include copper-transporting P-type ATPases, Menkes and Wilson proteins, and copper chaperones. These findings have paved the way towards better understanding of the role of copper deficiency or copper toxicity in physiological and pathological conditions. (C) 1999 Academic Press.