Identification of a major co-receptor for primary isolates of HIV-1
Identification of a major co-receptor for primary isolates of HIV-1
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DOI：
10.1038/381661a0
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发表时间：
1996-06-20
期刊：
影响因子：
64.8
通讯作者：
Landau, NR
中科院分区：
文献类型：
--
作者：
Deng, HK;Liu, R;Landau, NR
HIV - 1进入靶细胞需要细胞表面的CD4以及其他宿主细胞辅因子。最近鉴定出一种辅因子，它是感染在转化的T细胞系中适应生长的病毒所必需的，并被命名为融合素。然而，融合素并不能促进嗜巨噬细胞病毒的进入，而嗜巨噬细胞病毒被认为是体内关键的致病株。HIV - 1原发性嗜巨噬细胞毒株的包膜糖蛋白介导进入的主要辅因子是CC - CKR - 5，它是β趋化因子RANTES、MIP - 1α和MIP - 1β的受体。
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1 alpha and MIP-1 beta.