The Impact of Biology on Risk Assessment--workshop of the National Research Council's Board on Radiation Effects Research. July 21-22, 1997, National Academy of Sciences, Washington, DC.
The Impact of Biology on Risk Assessment--workshop of the National Research Council's Board on Radiation Effects Research. July 21-22, 1997, National Academy of Sciences, Washington, DC.
复制标题
生物学对风险评估的影响——国家研究委员会辐射效应研究研讨会。
作者：
R. Fry;A. Grosovsky;P. Hanawalt;R. Jostes;J. Little;W. Morgan;N. Oleinick;R. Ullrich
从高剂量电离辐射的剂量-反应关系到拟议的监管标准的剂量-反应关系的线性无阈值外推正受到一些科学家的挑战，另一些科学家则为其辩护。看来，与暴露于感兴趣剂量有关的风险低于流行病学研究可以衡量的风险。因此，许多人指望生物学提供与风险评估相关的信息。在这里报告的题为“生物学对风险评估的影响”的研讨会，计划通过将一直在生物学关键领域工作的科学家和其他一直在考虑与这一问题具体相关的问题的人聚集在一起，解决对更多信息的需求。讲习班的目标是总结和审查有关生物学的状况，确定所报告的生物学数据可能如何影响风险评估，并确定需要更多数据的主题。
The linear no-threshold extrapolation from a dose-response relationship for ionizing radiation derived at higher doses to doses for which regulatory standards are proposed is being challenged by some scientists and defended by others. It appears that the risks associated with exposures to doses of interest are below the risks that can be measured with epidemiological studies. Therefore, many have looked to biology to provide information relevant to risk assessment. The workshop reported here, "The Impact of Biology on Risk Assessment", was planned to address the need for additional information by bringing together scientists who have been working in key fields of biology and others who have been contemplating the issues associated specifically with this question. The goals of the workshop were to summarize and review the status of the relevant biology, to determine how the reported biological data might influence risk assessment, and to identify subjects on which more data are needed.
登录
查看更多内容
DOI：
10.1073/pnas.92.19.8876
发表时间：
1995-09-12
影响因子：
11.1
作者：
FORD, JM;HANAWALT, PC
通讯作者：
HANAWALT, PC
肿瘤坏死因子基因表达由电离辐射激活后的蛋白激酶 C 介导。
影响因子：
11.2
作者：
Hallahan,DE;Virudachalam,S;Sherman,ML;Huberman,E;Kufe,DW;Weichselbaum,RR
通讯作者：
Weichselbaum,RR
影响因子：
3.4
作者：
Little, JB;Nagasawa, H;Vetrovs, H
通讯作者：
Vetrovs, H
基因扩增过程中染色体不稳定。
影响因子：
5.3
作者：
Ruiz,JC;Wahl,GM
通讯作者：
Wahl,GM
通过转染 HPV16 E6 基因消除 p53 功能可增强人二倍体成纤维细胞对电离辐射的抵抗力。
DOI：
--
发表时间：
1995
期刊：
Oncogene.
影响因子：
--
作者：
Tsang,NM;Nagasawa,H;Li,C;Little,JB
通讯作者：
Little,JB