Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure.
Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure.
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DOI：
10.1289/ehp.887729
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发表时间：
1988-04
影响因子：
10.4
通讯作者：
McLachlan JA
中科院分区：
文献类型：
--
作者：
Bullock BC;Newbold RR;McLachlan JA
CD-1小鼠在妊娠第9 - 16天接受100 μ g己烯雌酚/kg体重给药，其雄性后代中隐睾和苗勒管结构保留的发生率较高。在许多DES处理的雄性小鼠中发现睾丸网和苗勒管结构增生，以及少量但显著数量的生殖道肿瘤。
Cryptorchidism and retention of Müllerian duct structures occur with high frequency among the male offspring of CD-1 mice treated with 100 micrograms diethylstilbestrol/kg body weight on days 9 through 16 of pregnancy. Hyperplasia of the rete testis and Müllerian duct structures were found in many of the DES-treated male mice, as was a low but significant number of reproductive tract neoplasms.