Intestinal microflora and immunoregulation
Intestinal microflora and immunoregulation
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DOI：
10.1038/mi.2008.52
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发表时间：
2008-11-01
影响因子：
8
通讯作者：
Butera, A.
中科院分区：
文献类型：
--
作者：
Boirivant, M.;Amendola, A.;Butera, A.
粘膜水平的免疫稳态来自对肠腔抗原的受控应答。最近对炎症性肠病性质的认识，主要来自对结肠炎症实验模型的研究，强烈表明它们可能是由于对细菌微生物区系中抗原的免疫耐受性丧失所致。在粘膜水平上操作的调节机制的调查表明，调节细胞反应的肠道菌群可能发挥作用，对不同抗原的交叉反应性保护。通过益生菌管理的微生物群反应性调节细胞的扩增能够保护免受实验性结肠炎。对正常肠道植物群的调节细胞的特征、它们发育的基础以及先天免疫在这一过程中的作用可能有助于理解炎症性肠病的发展。
Immune homeostasis at mucosal level results from controlled response to intestinal luminal antigens. Recent insights into the nature of inflammatory bowel diseases, derived mainly from studies of experimental models of colonic inflammation, strongly suggest that they can result from a loss of immune tolerance to antigens in the bacterial microflora. Investigations of the regulatory mechanisms operating at the mucosal level suggest that regulatory cells reactive to the intestinal microflora might play a role in cross-reactive protection toward different antigens. Expansion of microflora-reactive regulatory cells by probiotic administration is able to protect from experimental colitis. Characterization of regulatory cells in response to normal commensal flora, the basis of their development and the role of innate immunity in this process might contribute to the understanding of the development of inflammatory bowel diseases.