Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers
复制标题
DOI：
10.1038/sj.mp.4000532
复制
发表时间：
1999-05-01
影响因子：
11
通讯作者：
Sedvall, GC
中科院分区：
文献类型：
--
作者：
Jönsson, EG;Nöthen, MM;Sedvall, GC
纹状体多巴胺D2受体的密度在健康受试者中有很大差异。这种差异可能是由于遗传或环境因素造成的。在目前的分析中，我们寻找多巴胺D2受体基因（DRD2）多态性与体内纹状体多巴胺D2受体密度之间的关系，通过正电子发射断层扫描和[C-11]raclopride在56名健康受试者中测量。假设功能DRD2启动子等位基因（-141C Del）的存在与纹状体多巴胺受体高密度之间存在显著关联（t = 2.32, P = 0.02）。与先前的一些研究一致（2-4），DRD2 taqal等位基因的存在与低多巴胺受体密度相关（t = 2.58, P = 0.01）。DRD2 TaqIB1等位基因与低多巴胺受体密度相关（t = 2.58, P = 0.01），而另一种常见的内含子DRD2短序列重复多态性（STRP）与纹状体多巴胺D2受体密度无显著相关性。结果表明，DRD2基因型可能不同程度地参与了正常人纹状体多巴胺D2受体密度的调节。由于样本量有限，结果应谨慎解释。
The density of striatal dopamine D2 receptors has been shown to vary considerably among healthy subjects. This variability might be due to genetic or environmental factors. In the present analysis we searched for relationships between dopamine D2 receptor gene (DRD2) polymorphisms and striatal dopamine D2 receptor density in vivo, as measured by positron emission tomography and [C-11]raclopride in 56 healthy subjects. There was a significant association between presence of a putative functional DRD2 promoter allele (-141C Del) and high striatal dopamine receptor density (t = 2.32, P = 0.02). In agreement with some previous studies(2-4) the presence of the DRD2 TaqIAl allele was associated with measures of low dopamine receptor density (t = 2.58, P = 0.01). Also the DRD2 TaqIB1 allele was associated with low dopamine receptor density (t = 2.58, P = 0.01) whereas there was no significant relationship between another common silent intronic DRD2 short tandem repeat polymorphism (STRP) and striatal dopamine D2 receptor density. The results suggest that DRD2 genotypes may participate differentially in the regulation of striatal dopamine D2 receptor density in healthy human subjects. The results should be interpreted with caution because of the limited sample size.