Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis
Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis
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DOI：
10.3324/haematol.2015.136366
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发表时间：
2017-01-01
期刊：
影响因子：
10.1
通讯作者：
Goekbuget, Nicola
中科院分区：
文献类型：
--
作者：
Herold, Tobias;Schneider, Stephanie;Goekbuget, Nicola
费城样b细胞前体急性淋巴母细胞白血病（Ph-like ALL）在儿童和年轻人中具有明显的遗传改变和预后差的特点。本研究的目的是研究成人ph样ALL的遗传和临床特征。在207例患有b细胞前体ALL （BCP-ALL）的成人患者（中位年龄：42岁）中，26例（13%）通过基因表达谱被归类为ph样ALL。在95例BCR-ABL1和kmt2a重排阴性的BCP-ALL患者中，ph样ALL的发生率为27%。IGH-CRLF2重排（6/16；P=0.002）和JAK2突变(7/16；P=0.002
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 207 adult patients (median age: 42 years) with B-cell precursor ALL (BCP-ALL) were classified as having Ph-like ALL using gene expression profiling. The frequency of Ph-like ALL was 27% among 95 BCP-ALL patients negative for BCR-ABL1 and KMT2A-rearrangements. IGH-CRLF2 rearrangements (6/16; P=0.002) and mutations in JAK2 (7/16; P