[Studies on imipenem/cilastatin sodium in the perinatal period].
[Studies on imipenem/cilastatin sodium in the perinatal period].
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发表时间：
1988-11
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通讯作者：
N. Cho;K. Fukunaga;K. Kunii;I. Kobayashi;K. Tezuka
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作者：
N. Cho;K. Fukunaga;K. Kunii;I. Kobayashi;K. Tezuka
本文对亚胺培南/西司他丁钠（IPM/CS）在围产期的药代动力学、细菌学和临床应用进行了研究，结果如下：测定了IPM对羊水中金黄色葡萄球菌（敏感株和耐药株）和大肠杆菌（敏感株）细菌生长曲线的影响。IPM在羊水中的杀菌效果增加，对耐药菌株的杀菌效果显着增加。孕妇静脉滴注后立即检测到IPM和CS，并在给药后不久在母体血浆中达到峰值。IPM和CS对胎儿的胎盘渗透是有利的。静脉滴注500 mg/500 mg IPM/CS后，脐带血浆和羊水中的药物浓度超过了对主要病原微生物的MIC。IPM/CS治疗围产期感染临床疗效确切，无不良反应。上述结果表明IPM/CS是一种临床上有用的预防和治疗围产期感染的抗生素。
Pharmacokinetic, bacteriological and clinical studies of imipenem/cilastatin sodium (IPM/CS) were carried out in the perinatal period, and the results obtained are summarized as follows: Effects of IPM on bacterial growth curves of Staphylococcus aureus (sensitive and resistant strains) and Escherichia coli (sensitive strains) in amniotic fluid were determined. The bactericidal effects of IPM increased in amniotic fluid and remarkable increases against resistant strains were demonstrated. IPM and CS were detected promptly after intravenous drip infusion to pregnant women, and reached peak levels shortly after administration in maternal plasma. Placental penetration of IPM and CS to the fetus was favorable. After intravenous drip infusion of 500 mg/500 mg of IPM/CS, drug concentrations in the umbilical cord plasma and the amniotic fluid exceeded MICs against main pathogenic organisms. Clinically, IPM/CS was effective in the treatment of perinatal infections without any side effect. The above results demonstrated that IPM/CS is a clinically useful antibiotic for the prophylaxis and the treatment of perinatal infections.