Continuous rise in incidence of childhood Type 1 diabetes in Germany
Continuous rise in incidence of childhood Type 1 diabetes in Germany
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DOI：
10.1111/j.1464-5491.2008.02450.x
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发表时间：
2008-06-01
影响因子：
3.5
通讯作者：
Neu, A.
中科院分区：
文献类型：
--
作者：
Ehehalt, S.;Blumenstock, G.;Neu, A.
目的评估德国巴登-符腾堡州（BW）< 15岁儿童和青少年1型糖尿病（T1 DM）的发病率和发病趋势。方法BW是德国第三大联邦州。BW的所有31个儿科部门和一个糖尿病中心都参加了这项研究。根据EURODIAB标准进行病例登记。结果1987 ~ 2003年，广州市居民结核病年标化发病率为14.1/10万[95%可信区间（CI）为13.7，14.6，n = 4017]。发病率的估计年增长率为3.8%（95% CI 1.1，6.6）。与我们登记研究的前几年相比，目前T1 DM新发病例的平均数量翻了一番（1987-1989年，n = 153; 2000-2003年，n = 302）。一般来说，发病率上升最快的是0-4岁患者的最年轻年龄组（5.8%; 95% CI 2.5，9.3），其次是5-9岁年龄组（3.4%; 95% CI 0.8，6.0）和10-14结论在德国，儿童和青少年新发T1 DM的数量以比预期更快的速度增长。在德国观察到发病年龄明显向年轻化转变。
Aims To assess the incidence and the trend in incidence of Type 1 diabetes (T1DM) in children and adolescents < 15 years of age in Baden-Wurttemberg (BW), Germany.Methods BW is Germany's third largest federal state. All 31 paediatric departments in BW and one diabetes centre participated in the study. Case registration was done according to the EURODIAB criteria. The degree of ascertainment was 97.2%.Results From 1987 to 2003, the age- and sex-standardized incidence rate was 14.1/100 000 per year [95% confidence interval (CI) 13.7, 14.6, n = 4017]. The estimated annual increase in incidence was 3.8% (95% CI 1.1, 6.6). Compared with the first years of our registry, the current mean number of new cases of T1DM has doubled (1987-1989, n = 153; 2000-2003, n = 302). Generally, the highest rise in incidence occurred in the youngest age group of 0-4-year-old patients (5.8%; 95% CI 2.5, 9.3), followed by the age groups 5-9 (3.4%; 95% CI 0.8, 6.0) and 10-14 (2.7%; 95% CI 0.3, 5.1).Conclusions In Germany, the number of children and adolescents with new-onset T1DM has been rising at a faster pace than expected. A distinct shift to younger age at onset has been observed in Germany.