Tissue characterization using terahertz pulsed imaging in reflection geometry
Tissue characterization using terahertz pulsed imaging in reflection geometry
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DOI：
10.1088/0031-9155/54/1/010
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发表时间：
2009-01-07
影响因子：
3.5
通讯作者：
Pickwell-MacPherson, E.
中科院分区：
文献类型：
--
作者：
Huang, S. Y.;Wang, Y. X. J.;Pickwell-MacPherson, E.
太赫兹脉冲成像（TPI（TM））是一种非电离和非破坏性的成像技术，最近已被用于研究范围广泛的生物材料。太赫兹辐射在高含水量样品中的严重衰减意味着如果要在透射几何中测量生物样品，则需要非常薄。为了克服这一限制，可以在反射几何结构中测量样本，这是在临床环境中进行TPI的最可行方法。因此，在这项研究中，我们使用TPI的反射几何特征的太赫兹特性的几个器官样本新鲜收获的实验室大鼠。我们观察到测量的时域响应的差异，并确定了频率相关的光学特性，以进一步表征样品。我们发现组织类型之间存在统计学显著差异。这些结果表明，TPI具有准确区分非侵入性组织类型的潜力。
Terahertz pulsed imaging (TPI (TM)) is a non-ionizing and non-destructive imaging technique that has been recently used to study a wide range of biological materials. The severe attenuation of terahertz radiation in samples with high water content means that biological samples need to be very thin if they are to be measured in transmission geometry. To overcome this limitation, samples could be measured in reflection geometry and this is the most feasible way in which TPI could be performed in a clinical setting. In this study, we therefore used TPI in reflection geometry to characterize the terahertz properties of several organ samples freshly harvested from laboratory rats. We observed differences in the measured time domain responses and determined the frequency-dependent optical properties to characterize the samples further. We found statistically significant differences between the tissue types. These results show that TPI has the potential to accurately differentiate between tissue types non-invasively.