Helminth infection and cognitive impairment among Filipino children
Helminth infection and cognitive impairment among Filipino children
复制标题
DOI：
10.4269/ajtmh.2005.72.540
复制
发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
McGarvey, ST
中科院分区：
文献类型：
--
作者：
Ezeamama, AE;Friedman, JF;McGarvey, ST
本研究的目的是检查四种蠕虫（蛔虫、日本血吸虫、美洲钩虫和鞭虫）感染对认知功能的独立影响，调整了潜在的混杂因素营养状况、社会经济状况（SES）、血红蛋白、性别和其他蠕虫的存在。这项横断面研究是在菲律宾莱特的一个乡村进行的，共有319名7-18岁的儿童参加。采集三份粪便，并通过Kato Katz方法一式两份读取。感染强度由世界卫生组织标准定义。认知测试是文化适应和翻译。学习和记忆认知领域分别由记忆和学习的广泛评估的三个分量表定义，其评分员间信度>= 0.92，重测信度范围为0.61至0.89。管理家庭SES问卷。逻辑回归模型被用来量化在不同的认知领域（学习，记忆，语言流畅性，和菲律宾非语言智力测试）和蠕虫感染的性能之间的关联。在调整年龄、性别、营养状况、血红蛋白和社会经济地位后，S。日本血吸虫感染与学习成绩差有关（OR = 3.04，95%可信区间CI = 1.1-6.9）;蛔虫感染与记忆力测试成绩差相关（OR = 2.2，95%CI 1.04-4.7），鞭毛虫感染与语言流畅性测试成绩差相关（OR = 4.5，95%CI = 1.04-30）。在本研究中，蠕虫感染与四个认知领域中的三个认知领域的表现较低相关。在严格控制其他蠕虫和重要混杂协变量后，这些关系仍然存在。
The objective of this study was to examine the independent effect of infection with each of four helminths (Ascaris lumbricoides, Schistosoma japonicum, Necator americanus, and Trichuris trichiura) on cognitive function after adjusting for the potential confounders nutritional status, socioeconomic status (SES), hemoglobin, sex, and the presence of other helminthes. This cross-sectional study was carried out in a rural village in Leyte, The Philippines in 319 children 7-18 years old. Three stools were collected and read in duplicate by the Kato Katz method. Infection intensity was defined by World Health Organization criteria. Cognitive tests were culturally adapted and translated. Learning and memory cognitive domains were each defined by three subscales of the Wide Range Assessment of Memory and Learning, which had an inter-rater reliability >= 0.92 and test-retest reliabilities ranging from 0.61 to 0.89. A household SES questionnaire was administered. A logistic regression model was used to quantify the association between performance in different cognitive domains (learning, memory, verbal fluency, and the Philippine Non-Verbal Intelligence Test) and helminth infections. After adjusting for age, sex, nutritional status, hemoglobin, and SES, S. japonicum infection was associated with poor performance on tests of learning (odds ratio [OR] = 3.04, 95% confidence interval [CI] = 1.1-6.9), A. lumbricoides infection was associated with poor performance on tests of memory (OR = 2.2, 95% CI 1.04-4.7), and T trichiura infection was associated with poor performance on tests of verbal fluency (OR = 4.5, 95% CI = 1.04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates.