Dynamic balance deficit and the neural network in Alzheimer's disease and mild cognitive impairment
Dynamic balance deficit and the neural network in Alzheimer's disease and mild cognitive impairment
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DOI：
10.1016/j.gaitpost.2022.01.018
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发表时间：
2022-02-25
期刊：
影响因子：
2.4
通讯作者：
Arai, Tetsuaki
中科院分区：
文献类型：
--
作者：
Ide, Ryotaro;Ota, Miho;Arai, Tetsuaki
背景：阿尔茨海默病（AD）和轻度认知障碍（MCI）患者表现出平衡障碍。虽然只有少数研究评估了大脑图像和平衡指数之间的关系。在这项研究中，我们测量的平衡指数，包括姿势稳定性（IPS）的指数，并评估脑图像和他们的临床运动和认知功能feature.Methods：本研究包括MCI患者（N = 14）和AD患者（N = 19）之间的关系。主要结局是视觉阻滞条件和/或本体感觉阻滞条件下的IPS。此外，9例MCI和8例AD患者进行了1.5-T（1.5-T）磁共振成像（MRI）扫描，MRI参数和平衡indics.Results之间的关系进行了评估：IPS评分显着低于MCI组，但仅在闭眼/硬表面条件下，AD组。在MRI方面，有一个显着的正相关性IPS和区域介电centrality在左侧hippocampal regions.Conclusions：一个显着降低IPS评分下的闭眼/硬表面条件下，AD比MCI的情况下，表明前庭和/或本体感觉系统更严重的损害，AD比MCI的情况下。结果表明，由于前庭海马通路的赤字的动态平衡障碍可能是一个有用的标记物MCI的诊断和检测疾病进展从MCI到AD。
Background: Patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) exhibit balance deficits. Although only a few studies have evaluated the relationship between the brain images and balance indices. In this study, we measured balance indices, including the index of postural stability (IPS) and assessed the relationship between the brain images and their clinical motor and cognitive functional features.Methods: The study included patients with MCI (N = 14) and patients with AD (N = 19). The primary outcome was IPS under a visual block condition and/or a proprioception block condition. In addition, 9 MCI and 8 AD patients underwent a 1.5-Tesla (1.5-T) Magnetic Resonance Imaging (MRI) scan, and the relationships between the MRI parameters and the balance indices were evaluated.Results: The IPS score was significantly lower in the AD group than the MCI group, but only under the closed eyes/hard surface condition. In terms of MRI, there was a significant positive correlation between the IPS and the regional betweenness centrality in the left hippocampal region.Conclusions: The finding of a significantly lower IPS score under the closed eyes/hard surface condition in AD than in MCI cases suggests that the vestibular and/or proprioceptive systems were more severely impaired in AD than MCI cases. The results suggest that a dynamic balance disturbance due to deficits of the vestibular hippocampal pathway may be a useful marker for the diagnosis of MCI and detection of disease progression from MCI to AD.