The paradoxical role of methionine enkephalin in tumor responses
The paradoxical role of methionine enkephalin in tumor responses
复制标题
蛋氨酸脑啡肽在肿瘤反应中的矛盾作用
DOI：
10.1016/j.ejphar.2020.173253
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ming Xiang
中科院分区：
文献类型：
--
作者：
Yali Tuo;Cheng Tian;Lili Lu;Ming Xiang
Methionine enkephalin (MENK) is an opioid peptide composed of five.amino acids with multiple biological activities. Since its discovery, MENK has. become prominent in neuroregulation and immunoregulation. Tumors have. increasingly been a spotlight because of their terrible trends and refractory. characteristic. The therapeutic potential of MENK was investigated on a large scale,. and there are numerous evidences that MENK exerts anti-tumor effects via two. mechanisms. The first mechanism explains the enhanced anti-tumor immune effects. of MENK. The second mechanism shows that MENK directly inhibits tumor cell. proliferation. However, numerous reports have clarified the pro-tumor role of MENK. by inhibiting T and B cell proliferation, promoting tumor cell growth by binding to. opioid receptors, leading to desensitization of lymphocytes, and inducing tolerance. It. is particularly intriguing that dual reactions are triggered when MENK combines with. its opioid receptors; thus, anti-tumor response of the whole body is influenced. This. review will expound the dual roles of MENK in tumor responses based on immune. cells, cytokines, and tumor cells to provide better suggestions for its application in. tumor treatment.
