Fundus autofluorescence and age-related macular degeneration
Fundus autofluorescence and age-related macular degeneration
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DOI：
10.1016/s0161-6420(02)01756-6
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发表时间：
2003-02-01
期刊：
影响因子：
13.7
通讯作者：
Spaide, RF
中科院分区：
文献类型：
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作者：
Spaide, RF
目的：评估非渗出性年龄相关性黄斑变性 (AMD) 患者和渗出性年龄相关性黄斑变性 (AMD) 患者眼睛的自发荧光图像。设计：观察病例系列。参与者：在作者的实践中看到的 54 名患者。方法：使用基于眼底相机的自发荧光照片系统，激发 (580 nm) 和屏障 (695 nm) 滤光片的波长基于已知的眼部透射和自发荧光特性媒体。还用无红光和红外单色成像对患者进行拍照。比较没有渗出性 AMD 的患者（第 1 组）和渗出性 AMD 的患者之间的自发荧光平均水平。对渗出性 AMD 患者进行比较，检查渗出过程中无视网膜血管贡献的患者（第 2 组）与有视网膜血管贡献的患者（第 3 组）的自发荧光模式。主要结果指标：自发荧光的平均数量和模式。结果：总共评估了 54 名患者；每组18人。平均年龄为75.4岁，各组之间的平均年龄没有差异（P = 0.16）。自发荧光测量与核硬化程度没有相关性（P = 0.14）。渗出性 AMD 患者的另一只眼比无渗出性 AMD 患者的眼睛有更多的自发荧光 (P = 0.002)。与第 2 组患者相比，第 3 组患者更可能出现局灶性色素沉着过度，特别是通过红外光成像 (P = 0.015) 和强烈自发荧光的局部区域 (P = 0.001)。结论：通过使用这种自发荧光成像方法，确定渗出性 AMD 患者的对侧眼比没有渗出性 AMD 病史的患者的眼睛具有更多的自发荧光。患有渗出性 AMD 血管增生的视网膜血管吻合的患者更有可能在其对侧眼中出现强烈自发荧光的焦点区域，这在很大程度上与红外单色眼底摄影最能看到的色素沉着过度焦点区域相对应。由于荧光量与脂褐素的量直接相关，而脂褐素的量又与氧化损伤的累积量相关，因此这些发现为渗出性 AMD 中所见的某些血管生长模式提供了可能的解释。眼科 2003；110:392-399 (C) 2003 年，美国眼科学会。
Purpose: To evaluate the autofluorescence images of patients with nonexudative and the fellow eyes with exudative age-related macular degeneration (AMD).Design: Observational case series.Participants: Fifty-four patients seen in the author's practice.Methods: A fundus camera-based system for autofluorescence photographs was used, and the wavelengths for the excitation (580 nm) and barrier (695 nm) filters were based on known transmission and autofluorescent characteristics of the ocular media. Patients were also photographed with red-free and infrared monochromatic imaging. The mean levels of autofluorescence were compared between patients without (group 1) and those with exudative AMD. Comparisons were made among patients with exudative AMD, examining the autofluorescence pattern in those without retinal vascular contribution to the exudative process (group 2) to those with retinal vascular contribution (group 3).Main Outcome Measures: Mean amounts and patterns of autofluorescence.Results: A total of 54 patients was evaluated; 18 were in each group. The mean age was 75.4 years, and there was no difference in the mean ages among the groups (P = 0.16). There was no correlation of the autofluorescence measurements and the degree of nuclear sclerosis (P = 0.14). Patients with exudative AMD had more autofluorescence in the fellow eye than did eyes of patients without exudative AMD (P = 0.002). Patients in group 3 were more likely to have focal hyperpigmentation, particularly as imaged by infrared light (P 0.015), and focal areas of intense autofluorescence (P = 0.001) than were patients in group 2.Conclusions: By use of this method of autofluorescence imaging, it was determined that the fellow eyes of patients with exudative AMD had larger amounts of autofluorescence than did the eyes of patients without a history of exudative AMD. Patients with retinal vascular anastomosis to the vascular proliferation of exudative AMD were much more likely to have focal areas of intense autofluorescence in their fellow eye that corresponded, for the most part, with focal areas of hyperpigmentation best seen by infrared monochromatic fundus photography. Because the amount of fluorescence is directly related to the amount of lipofuscin, which in turn is related to the cumulative amount of oxidative damage, these findings suggest possible explanations for certain patterns of vessel growth seen in exudative AMD. Ophthalmology 2003;110:392-399 (C) 2003 by the American Academy of Ophthalmology.