Hepatic lesions in young rabbits experimentally infected with rabbit haemorrhagic disease virus
Hepatic lesions in young rabbits experimentally infected with rabbit haemorrhagic disease virus
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DOI：
10.1053/rvsc.1998.0266
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发表时间：
1999-06-01
影响因子：
2.4
通讯作者：
Itakura, C
中科院分区：
文献类型：
--
作者：
Mikami, D;Park, JH;Itakura, C
采用兔出血性疾病病毒（RHDV）对20只幼兔（11只2周龄，9只4周龄）进行感染实验，以明确其易感性。按时间顺序杀死接种后96小时（PI），并检查病变。所有接种的家兔在临床上均正常，但在整个肝脏中发现微小的白色或灰色斑点。组织学上，病变由淋巴细胞、巨噬细胞和嗜杂细胞聚集而成，伴或不伴嗜酸小体和坏死肝细胞。免疫组化结果显示，在退行性肝细胞和巨噬细胞中发现RHDV抗原。细胞聚集被认为是对感染了RHDV的坏死肝细胞的反应。结果表明，幼兔部分肝细胞对RHDV易感。
Twenty young rabbits (eleven 2-week-old and nine 4-week-old) were experimentally infected with rabbit haemorrhagic disease virus (RHDV) to clarify susceptibility. They were killed chronologically up to 96 hours post-inoculation (PI) and examined for lesions. All inoculated rabbits were clinically normal, but grossly minute white or grey spots were detected throughout the liver. Histologically, the lesions consisted of aggregates of lymphocytes, macrophages and heterophils, with or without acidophilic bodies and necrotic hepatocytes. Immunohistochemically, RHDV antigens were found in the degenerated hepatocytes and in macrophages. The cellular aggregates were considered to be a reaction to necrotic hepatocytes infected with RHDV. It was concluded that some hepatocytes are susceptible to RHDV in young rabbits.