A Population‐Based Study of Childhood Acute Lymphoblastic Leukemia Diagnosed from July 1981 through June 1985 in the Five Nordic Countries
A Population‐Based Study of Childhood Acute Lymphoblastic Leukemia Diagnosed from July 1981 through June 1985 in the Five Nordic Countries
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对北欧五国 1981 年 7 月至 1985 年 6 月诊断的儿童急性淋巴细胞白血病的人群研究
DOI：
10.1111/j.1651-2227.1987.tb10565.x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
L. Åhström
中科院分区：
文献类型：
--
作者：
G. Gustafsson;S. Garwicz;H. Hertz;G. Johanesson;G. Jonmundsson;P. J. Moe;T. Salmi;M. Seip;M. Siimes;M. Yssing;L. Åhström
自1981年7月至1985年6月，北欧五国(丹麦、芬兰、冰岛、挪威和瑞典)共确诊急性淋巴细胞性白血病(ALL)儿童656例。ALL的年发病率为3.615岁儿童中的3.6%，男性发病率为3.8%，女性发病率为3.4%。一半的儿童确诊时年龄在5岁以下，发病高峰在2-3岁之间。根据诊断时的预后标准，将白血病分为标准风险(SR)、中危(IR)和高危(HR)白血病。缓解率为95%。诊断为非B细胞ALL的1岁儿童的无事件生存率(EFS)为0.58；SR-儿童为0.65，IR-儿童为0.51，HR-儿童为0.52。诊断时白细胞计数是最重要的预后因素，白细胞计数在11~20×109/L与所有白细胞数值中预后最差(EFS=0.30)，与其他预后因素无关。男性是影响预后的第二大不良指标。1986年1月随访(观察时间6~54个月)，656例患儿中442例(67%)完全持续缓解。总的结果表明，通过更密集的治疗，大多数风险组的预后都有可能得到改善。
Six hundred and fifty‐six children with acute lymphoblastic leukemia (ALL) have been diagnosed in the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) during the period from July 1981 through June 1985. Annual incidence of ALL was 3.6/100000 children aged < 15 years, with an incidence for males of 3.8 and for females of 3.4 respectively. Half of the children were younger than 5 years of age at diagnosis, with a peak incidence between 2–3 years of age. The leukemias were classified as Standard Risk (SR), Intermediate Risk (IR) or High Risk (HR) leukemia according to prognostic criteria at diagnosis. The remission rate was 95%. In children 1 year of age with non‐B‐cell ALL at diagnosis, the Event‐Free Survival (EFS) was 0.58; 0.65 for SR‐children, 0.51 for IR‐children and 0.52 for HR‐children. WBC count at diagnosis was the most important prognostic factor and a WBC count of 11‐20×109/l was associated with the worst prognosis of all WBC values (EFS=0.30), independent of other prognostic factors. Male sex was the second most important adverse prognostic criterion. The follow‐up in January 1986 (observation time 6–54 months), showed that 442 of the 656 children (67%) were in complete continuous remission. The total results indicate a possibility to improve the prognosis for most of the risk groups of ALL with a more intensive treatment.
影响因子：
158.5
作者：
CLAVELL, LA;GELBER, RD;SALLAN, SE
通讯作者：
SALLAN, SE