Neuropeptide Y is an angiogenic factor in cardiovascular regeneration.
Neuropeptide Y is an angiogenic factor in cardiovascular regeneration.
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DOI：
10.1016/j.ejphar.2016.02.033
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发表时间：
2016-04
影响因子：
5
通讯作者：
R. Saraf;Feroze Mahmood;Rabia Amir;R. Matyal
中科院分区：
文献类型：
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作者：
R. Saraf;Feroze Mahmood;Rabia Amir;R. Matyal
在糖尿病性心肌病中，存在改变的血管生成信号和增加的氧化应激。因此，抗血管生成和促炎途径被激活。这些破坏细胞代谢并引起纤维化和凋亡，导致病理性重塑。自主神经系统和神经递质在血管生成中起重要作用。促进血管生成的疗法可能能够缓解这些疾病状态中的病理。神经肽Y（neuropeptide Y，NPY）是哺乳动物中枢和外周神经系统中产生和表达最丰富的一种神经肽，在促进血管生成和心肌细胞重塑中发挥重要作用。它通过广泛分布并存在于心肌上的G蛋白偶联Y受体产生作用。这些受体中的一些也与心脏的疾病状态有关。NPY是一种有效的生长因子，在多种系统中引起细胞增殖，而NPY 3 - 36片段在刺激血管生成和心肌细胞重塑中具有选择性。目前的研究集中在开发一种NPY的药物输送机制，以延长治疗而不会产生显着的全身性后果。这可能是治疗糖尿病性心肌病和缺血性心脏病的一个有前途的创新。
In diabetic cardiomyopathy, there is altered angiogenic signaling and increased oxidative stress. As a result, anti-angiogenic and pro-inflammatory pathways are activated. These disrupt cellular metabolism and cause fibrosis and apoptosis, leading to pathological remodeling. The autonomic nervous system and neurotransmitters play an important role in angiogenesis. Therapies that promote angiogenesis may be able to relieve the pathology in these disease states. Neuropeptide Y (NPY) is the most abundantly produced and expressed neuropeptide in the central and peripheral nervous systems in mammals and plays an important role in promoting angiogenesis and cardiomyocyte remodeling. It produces effects through G-protein-coupled Y receptors that are widely distributed and also present on the myocardium. Some of these receptors are also involved in diseased states of the heart. NPY has been implicated as a potent growth factor, causing cell proliferation in multiple systems while the NPY3-36fragment is selective in stimulating angiogenesis and cardiomyocyte remodeling. Current research is focusing on developing a drug delivery mechanism for NPY to prolong therapy without having significant systemic consequences. This could be a promising innovation in the treatment of diabetic cardiomyopathy and ischemic heart disease.