Role of FSH in the control of testicular function.
Role of FSH in the control of testicular function.
复制标题
FSH 在控制睾丸功能中的作用。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
A. Davies
中科院分区：
文献类型：
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作者：
A. Davies
Follicle stimulating hormone (FSH) binds to the plasma membranes of Sertoli cells and, apparently, spermatogonia; the hormone may then be taken into the cytoplasm of its target cells and metabolized there. In the immature testis, binding of FSH to Sertoli cells leads to activation of adenylate cyclase, formation of cyclic AMP (cAMP), and activation of a cAMP-dependent protein kinase. There is a subsequent increase in the rates of RNA, protein, and DNA synthesis. Normal adult testis is unresponsive to FSH, one reason being the destruction of cAMP by a phosphodiesterase. After hypophysectomy of adult animals this enzyme disappears and FSH is again able to stimulate RNA and protein synthesis. Other factors contributing to the insen-sitivity of the mature testis are an FSH binding inhibitor, a protein kinase inhibitor, and in-activation of FSH.FSH increases the formation by Sertoli cells of structural proteins and an androgen-binding protein (ABP) that the Sertoli cells secrete into the extracellular fluid su...
