Brief communication: heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from the SCID mouse.
Brief communication: heat-induced accumulation of p53 and hsp72 is suppressed in lung fibroblasts from the SCID mouse.
复制标题
简要交流：SCID 小鼠肺成纤维细胞中热诱导的 p53 和 hsp72 积累受到抑制。
DOI：
10.1080/095530000138385
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发表时间：
2000
影响因子：
2.6
通讯作者：
H. Matsumoto
中科院分区：
文献类型：
--
作者：
T. Ohnishi;K. Komatsu;H. Tauchi;X. Wang;A. Takahashi;K. Ohnishi;A. Shiba;H. Matsumoto
目的
PURPOSE
To investigate how DNA-dependent protein kinase (DNA-PK) contributes to p53-dependent signal transduction after heat shock, thermosensitivity and accumulation of p53 and hsp72 after heat shock in lung fibroblasts derived from the SCID mouse were analysed.
MATERIALS AND METHODS
Thermosensitivity at 44 degrees C in colony-forming units and Western blot analysis of p53 and hsp72 were analysed.
RESULTS
The results indicated that (1) the thermosensitivity at 44 degrees C of SCID cells was higher than that of parental cells and (2) heat-induced accumulation of p53 and hsp72 was abolished and suppressed in SCID cells as compared with that in parental cells respectively.
CONCLUSIONS
The findings suggest that the catalytic subunit of DNA-PK may play an important role upstream of p53 and hsp72, which are possible determinants of cellular thermosensitivity.
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影响因子：
11.2
作者：
W. Rathmell;W. Kaufmann;J. Hurt;L. L. Byrd-L.;G. Chu
通讯作者：
W. Rathmell;W. Kaufmann;J. Hurt;L. L. Byrd-L.;G. Chu
影响因子：
56.9
作者：
Canman, CE;Lim, DS;Siliciano, JD
通讯作者：
Siliciano, JD
人 hsp70 在大鼠成纤维细胞中的表达可增强细胞存活率，并促进热休克后翻译和转录抑制的恢复。
影响因子：
11.2
作者：
Liu,RY;Li,X;Li,L;Li,GC
通讯作者：
Li,GC
DOI：
10.1073/pnas.89.24.11920
发表时间：
1992-12-15
影响因子：
11.1
作者：
DVIR, A;PETERSON, SR;DYNAN, WS
通讯作者：
DYNAN, WS
DOI：
10.1073/pnas.92.16.7515
发表时间：
1995-08-01
影响因子：
11.1
作者：
SIPLEY, JD;MENNINGER, JC;ANDERSON, CW
通讯作者：
ANDERSON, CW