Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
Hypoxia-inducible factor 1: Control of oxygen homeostasis in health and disease
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DOI：
10.1203/00006450-200105000-00002
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发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Semenza, CL
中科院分区：
文献类型：
--
作者：
Semenza, CL
缺氧诱导因子1（HIF-1）是一种转录激活因子，介导基因表达的变化，以响应细胞氧浓度的变化。HIF-1是由氧调节的HIF-1 α亚基和组成型表达的HIF-1 β亚基组成的异源二聚体。在小鼠中，由于心脏和血管畸形，完全缺乏HIF-1 α会导致妊娠中期的胚胎死亡。对动物和细胞培养模型以及人体组织的分析提供了证据，表明HIF-1在先兆子痫、宫内生长迟缓、缺氧介导的肺动脉高压和癌症的病理生理学中起重要作用。HIF-1通过激活编码血管内皮生长因子的基因的转录来促进对心肌或视网膜缺血的响应的新血管形成。HIF-1还可能介导对脑缺血的保护反应，称为晚期预适应。
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that mediates changes in gene expression in response to changes in cellular oxygen concentrations. HIF-1 is a heterodimer consisting of an oxygen-regulated HIF-1 alpha subunit and a constitutively expressed HIF-1 beta subunit. In mice, complete HIF-1 alpha deficiency results in embryonic lethality at midgestation because of cardiac and vascular malformations. Analyses of animal and cell culture models as well as human tissue have provided evidence that HIF-1 plays important roles in the pathophysiology of preeclampsia, intrauterine growth retardation, hypoxia-mediated pulmonary hypertension, and cancer. HIF-1 pro motes neovascularization in response to myocardial or retinal ischemia by activating transcription of the gene encoding vascular endothelial growth factor. HIF-1 may also mediate the protective response to cerebral ischemia known as late-phase preconditioning.