Evaluating the quality of life of patients with restless legs syndrome
Evaluating the quality of life of patients with restless legs syndrome
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DOI：
10.1016/s0149-2918(04)90136-1
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发表时间：
2004-06-01
影响因子：
3.2
通讯作者：
Knight, H
中科院分区：
文献类型：
--
作者：
Abetz, L;Allen, R;Knight, H
背景：不宁腿综合征（RLS）的主要发病机制包括睡眠丧失、极度不适和正常活动中断。虽然这种情况不会危及生命，但评估疾病负担和RLS对生活质量（QOL）的影响对于评估治疗获益至关重要。目的：本研究的目的是评估RLS对QOL的影响。方法：在特定验证研究的子分析中，SF-36（医学结果研究36项简表健康调查）对85名已被转诊到睡眠医学诊所的原发性RLS患者进行管理。这些分数与公布的一般人群的标准进行了比较（N = 2474）。大多数63.5%的RLS患者为女性，平均（SD）年龄为62.4（14.0）岁67.1%的患者几乎每天都出现RLS症状。RLS组，特别是具有更严重RLS的患者，与普通人群相比，报告了身体功能、角色-身体、身体疼痛、一般健康、活力、社会功能和角色-情感方面的显著缺陷（100分量表上的10-40分）。与高血压患者相比，RLS样本在SF-36的所有8个量表上的评分均显著较低（QOL较差）（P < 0.01）;与其他心血管疾病患者（即充血性心力衰竭、过去一年内的心肌梗死和心绞痛）相比，RLS组在8个量表中的6个量表上的评分较低。RLS患者有较低的评分7 8量表与糖尿病患者相比，4 8量表与骨关节炎patients.Conclusions：比较的SF-36评分的RLS患者和正常的一般人群表明，该疾病对患者的生活质量有显着的影响。版权所有（C）2004 Excerpta Medica，Inc.
Background: The primary morbidities of restless legs syndrome (RLS) involve sleep loss, extreme discomfort, and disruption of normal activities. Although the condition is not life-threatening, assessing the disease burden and the impact of RLS on quality of life (QOL) is critical for evaluating treatment benefits.Objective: The purpose of this study was to assess the impact of RLS on QOL.Methods: in this subanalysis of a specific validation study, the SF-36 (Medical Outcomes Study 36-Item Short Form health survey) was administered to 85 patients with primary RLS who had been referred to a sleep-medicine clinic. The scores were compared with published norms for the general population (N = 2474).Results: The majority (63.5%) of RLS patients were women the mean (SD) age was 62.4 (14.0) years 67.1% of patients experienced RLS symptoms almost daily The RLS group, particularly patients with more severe RLS, reported significant deficits (10-40 points on 100-point scales) in physical functioning, role-physical, bodily pain, general health, vitality, social functioning, and role-emotional compared with the general population. The RLS sample had significantly lower scores (worse QOL) on all 8 scales of the SF-36 compared with patients with hypertension (P < 0.01); compared with patients with other cardiovascular conditions (ie, congestive heart failure, myocardial infarction within the past year, and angina), the RLS group had lower scores on 6 of the 8 scales. RLS patients had lower scores on 7 of 8 scales compared with diabetes patients, and on 4 of 8 scales compared with osteoarthritis patients.Conclusions: Comparison of the SF-36 scores of patients with RLS and the normative general population suggests that the disorder has a significant impact on patient QOL. Copyright (C) 2004 Excerpta Medica, Inc.