Differential effects of lipopolysaccharide in the social behavior of dominant and submissive mice
Differential effects of lipopolysaccharide in the social behavior of dominant and submissive mice
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DOI：
10.1016/j.physbeh.2006.02.011
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发表时间：
2006-05-30
影响因子：
2.9
通讯作者：
de Sa-Rocha, Luiz Carlos
中科院分区：
文献类型：
--
作者：
Cohn, Daniel Wagner Hamada;de Sa-Rocha, Luiz Carlos
急性感染的动物表现出一系列非特异性的行为变化，称为病态行为。最近的研究表明，疾病行为的发生是根据动机的角度进行调节的。因此，病态行为的表现可能会与其他行为的表现竞争。在这项工作中，我们试图确定脂多糖（LPS）给药（15 μ g/小鼠i. p.）在支配型和顺从型老鼠的社会行为中的作用。结果表明，社会等级影响疾病行为的表达。虽然用LPS处理的显性小鼠显示出所显示的行为的总频率的预期降低，但在对顺从小鼠进行相同处理后，这种降低并没有发生。在社交和攻击行为方面也有类似的结果。使用动机的角度提供了一个假设，由于他们的高社会地位，占主导地位的小鼠能够优先恢复行为。另一方面，即使用LPS治疗，顺从的小鼠似乎基本上专注于社会防御行为，因为它们仍然存在于占主导地位的个体中。疾病对小鼠等级组织的影响仍有待进一步研究。(c)2006年爱思唯尔公司All rights reserved.
Acutely infected animals show a set of non-specific behavioral changes known as sickness behavior. Recent studies have shown that occurrence of sickness behavior is regulated according to a motivational perspective. Thus, the display of sickness behavior may compete with display of other behaviors. In this work, we sought to determine the effects of lipopolysaccharide (LPS) administration (15 mu g/mouse i.p.) in the social behavior of dominant and submissive mice. Results showed that social hierarchy influences the expression of sickness behavior. While dominant mice treated with LPS showed an expected reduction in total frequency of behaviors displayed, such decrease did not happen following the same treatment to submissive mice. Similar results occurred regarding social and aggressive behavior. The use of a motivational perspective provides the assumption that, due to their high social ranking, dominant mice were able to prioritize recuperative behavior. Submissive mice, on the other hand, even though treated with LPS, seemed to essentially focus on social defensive behaviors since they remained in the presence of the dominant individuals. Effects of sickness on the hierarchical organization of mice remain to be further investigated. (c) 2006 Elsevier Inc. All rights reserved.