Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by streptozotocin and high-fat, high-sugar diet
Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by streptozotocin and high-fat, high-sugar diet
复制标题
六堡茶提取物可缓解链脲佐菌素和高脂高糖饮食诱导的大鼠糖尿病并调节肠道微生物群
DOI：
10.1016/j.biopha.2019.109262
复制
发表时间：
2019-10-01
影响因子：
7.5
通讯作者：
Ma, Baiping
中科院分区：
文献类型：
--
作者：
Ding, Qianzhi;Zhang, Bowei;Ma, Baiping
六泡茶是一种受欢迎的黑茶，在中国茶文化中表现出抗糖尿病的活性。然而，主要活性成分的生物利用度较低。因此，本研究首次研究了抗糖尿病活性与肠道微生物群调节之间的关系。六泡茶提取物（LTE）可显著降低高血糖、胰岛素抵抗和血脂水平。高剂量LTE的降血糖作用与二甲双胍相当。重要的是，LTE在调节糖尿病诱导的肠道微生物群紊乱方面表现出有益的作用，例如增加拟杆菌/厚壁菌门的比例和上调推定的短链脂肪酸（SCFA）产生细菌，包括普雷沃氏菌和拟杆菌。此外，29种关键的糖尿病类型与至少一种糖尿病指数显著相关。总之，LTE可以开发成抗糖尿病功能饮料，其有益效果可能与增加SCFA水平和SCFA产生菌相对丰度的益生元效应有关。
Liupao tea, a popular dark tea, exhibited anti-diabetic activity in Chinese tea culture. However, the bioavailability of the main active components is low. Therefore, the relationship between the anti-diabetic activity and the modulation of gut microbiota was investigated in this study for the first time. Liupao tea extract (LTE) could significantly alleviate hyperglycemia, insulin-resistance, and plasma lipid profiles. The hypoglycemic effect of high-dose LTE was comparable to that of metformin. Importantly, LTE exhibited beneficial effect on modulating the diabetic-induced disorder of gut microbiota, such as increasing Bacteroidetes/Firmicutes ratio and up-regulating putative short-chain fatty acid (SCFA)-producing bacteria, including Prevotella and Bacteroides. Moreover, 29 key phylotypes were significantly correlated with at least one diabetic index. In conclusion, LTE could be developed into an anti-diabetic functional beverage and its beneficial effects is likely to be associated with the prebiotic effects for increasing the level of SCFAs and the relative abundance of SCFA-producing bacteria.