Evidence for a systemic role for ovarian oxytocin in luteal regression in sheep.
Evidence for a systemic role for ovarian oxytocin in luteal regression in sheep.
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卵巢催产素在绵羊黄体退化中发挥全身作用的证据。
DOI：
10.1530/jrf.0.0670215
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
E. Sheldrick
中科院分区：
文献类型：
--
作者：
A. Flint;E. Sheldrick
颈静脉催产素和孕酮的浓度在发情周期中的母羊平行变化，在黄体退化下降，并与新的黄体形成上升。催产素循环浓度的波动不是由其代谢清除率的变化引起的。在周期的第6-9天，循环催产素浓度表现出昼夜节律，在09：00 h达到峰值;第11-14天不存在这种节律。虽然没有证据表明在每日采集的样本中黄体退化时或之前催产素的产生增加，但更频繁的采样显示，三分之二检测到的子宫前列腺素（PG）F-2 α分泌激增伴随着催产素水平的升高。这种催产素不是垂体来源的。发情后第8天氯前列烯醇诱导的黄体消退导致循环孕酮水平降低，24小时后催产素下降。氯前列醇治疗前后卵巢和其他器官中催产素的测量结果表明，黄体是催产素的主要潜在来源，并表明98%的黄体催产素可用于对前列腺素刺激的分泌。这些数据与卵巢分泌催产素对子宫释放PGF-2 α的反应在控制黄体退化中的作用一致。
Jugular venous concentrations of oxytocin and progesterone changed in parallel during the oestrous cycle in the ewe, falling at luteal regression and rising with formation of the new corpus luteum. These fluctuations in the circulating concentration of oxytocin were not caused by changes in its metabolic clearance rate. On Days 6-9 of the cycle circulating oxytocin concentrations exhibited a diurnal rhythm, peaking at 09:00 h; this rhythm was absent on Days 11-14. Although there was no evidence for increased production of oxytocin at or preceding luteal regression in samples taken daily, more frequent sampling revealed that two thirds of detected surges of uterine secretion of prostaglandin (PG) F-2 alpha were accompanied by raised levels of oxytocin. This oxytocin was not of pituitary origin. Luteal regression induced with cloprostenol on Day 8 after oestrus caused a decrease in circulating progesterone level followed after 24 h by a fall in oxytocin. Measurements of oxytocin in the ovary and other organs before and after treatment with cloprostenol identified the corpora lutea as a major potential source of oxytocin, and suggested that 98% of luteal oxytocin was available for secretion in response to prostaglandin stimulation. The data are consistent with a role for ovarian secretion of oxytocin in response to uterine release of PGF-2 alpha in the control of luteal regression.