Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation
Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation
复制标题
西方饮食中的脂肪和碳水化合物对肝脏脂质积累的贡献不同
DOI：
10.1016/j.bbrc.2015.04.092
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发表时间：
2015
影响因子：
3.1
通讯作者：
Katsumi Iizuka
中科院分区：
文献类型：
--
作者：
Wudelehu Wu;Hiromi Tsuchida;Takehiro Kato;Horoyuki Niwa;Yukio Horikawa;Jun Takeda;Katsumi Iizuka
我们研究了膳食脂肪和膳食碳水化合物对西方饮食（WD）诱发的脂肪肝发展的贡献。与WD喂养的野生型（WT）小鼠相比，WD喂养的ChREBP−/−小鼠的肝脏在肝小叶周围出现不同大小的脂滴，而肝脏甘油三酯和胆固醇含量仅略有下降。 ChREBP−/− 小鼠的炎症和纤维化受到抑制。此外，与WD喂养的WT小鼠相比，ChREBP−/−小鼠表现出β-氧化、生酮和FGF21产生减少、肠道脂质吸收增加以及VLDL分泌减少。这些发现表明膳食脂肪和碳水化合物对脂肪肝的发展有不同的贡献。
We investigated the contributions of dietary fat and dietary carbohydrate to the development of fatty liver induced by western diet (WD). Compared with WD-fed wild type (WT) mice, livers of WD-fed ChREBP−/−mice showed lipid droplets of varying sizes around the hepatic lobules, while hepatic triglyceride and cholesterol contents were only modestly decreased. Inflammation and fibrosis were suppressed in ChREBP−/−mice. In addition, compared with WD-fed WT mice, ChREBP−/−mice showed decreased β-oxidation, ketogenesis and FGF21 production, increased intestinal lipid absorption, and decreased VLDL secretion. These findings suggest that dietary fat and carbohydrate contribute differently to the development of fatty liver.