Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis
Evaluation of Urinary Biomarkers for the Prognosis of Drug-associated Chronic Tubulointerstitial Nephritis
复制标题
尿液生物标志物对药物相关慢性肾小管间质性肾炎预后的评估
DOI：
10.1097/maj.0b013e318271f910
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Li Yang
中科院分区：
文献类型：
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作者：
Yin;T. Su;L. Qu;Caili Wang;Xiaomei Li;Li Yang
背景：尿生物标志物预测药物性慢性肾小管间质性肾炎（D-CTIN）不良临床结局的有效性尚未得到很好的描述。方法：对54例D-CTIN患者进行前瞻性随访。测定基线时尿1-微球蛋白和转化生长因子-1的排泄量以及尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和基质金属蛋白酶（MMPs）2和9的活性。记录11至54个月（中位数，38个月）随访期间估计肾小球滤过率（GFR）的变化。测试了尿生物标志物用于区分具有各种结果的患者的功效。10例伊加肾病患者和20例健康志愿者作为对照。结果：尿NAG、MMP-9、MMP-2和β 1-微球蛋白预测GFR恶化的受试者工作特征曲线下面积分别为0.879、0.867、0.735和0.709（均P < 0.05）。偏回归分析显示，尿NAG（P = 0.02）、MMP-2（P = 0.046）和MMP-9（P = 0.041）与GFR下降率呈负相关。结论：尿NAG、MMP-2和MMP-9可作为预测D-CTIN进展速度的可能候选指标。
Background:The efficacy of urinary biomarkers for predicting adverse clinical outcomes in drug-induced chronic tubulointerstitial nephritis (D-CTIN) has not been well described. Methods:A total of 54 patients with D-CTIN were prospectively followed-up in this study. The urinary excretion of &agr;1-microglobulin and transforming growth factor-&bgr;1 and the activity of urinary N-acetyl-&bgr;-D-glucosaminidase (NAG) and matrix metalloproteinases (MMPs) 2 and 9 at baseline were measured. Changes in the estimated glomerular filtration rate (GFR) over a period of 11 to 54 months (median, 38 months) of follow-up were recorded. The efficacy of urinary biomarkers for differentiating patients with various outcomes was tested. Ten patients with IgA nephropathy and 20 healthy volunteers were enrolled as controls. Results:The areas under the receiver operating characteristic curve for urinary NAG, MMP-9, MMP-2 and &agr;1-microglobulin for predicting deterioration of the estimated GFR were 0.879, 0.867, 0.735 and 0.709, respectively (P < 0.05 for all). Partial regression coefficient results demonstrated that urinary NAG (P = 0.02), MMP-2 (P = 0.046) and MMP-9 (P = 0.041) were inversely correlated with the rate of GFR decline. Conclusions:Urinary NAG, MMP-2 and MMP-9 may be considered as possible candidates for forecasting the progression rate of D-CTIN.
关于脊椎动物基质金属蛋白酶及其组织抑制剂的文献。
DOI：
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发表时间：
1992
期刊：
Matrix (Stuttgart, Germany). Supplement
影响因子：
--
作者：
WoessnerJr,JF
通讯作者：
WoessnerJr,JF