Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality
Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality
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DOI：
10.1073/pnas.0308538101
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发表时间：
2004-06-29
影响因子：
11.1
通讯作者：
Bressler, SL
中科院分区：
文献类型：
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作者：
Brovelli, A;Ding, MZ;Bressler, SL
先前的研究表明，初级运动皮层中同步的β频率（14-30 Hz）振荡参与维持对侧臂和手部肌肉的稳定收缩。但是，对于后中央皮质区域在运动维持中的作用及其与运动皮层的相互作用模式，知之甚少。我们调查了两只猴子前后中心区域和后中性区域中β同步神经元组件的功能关系，因为它们在视觉歧视任务的等待期间按下了手持杆。通过使用功率和相干频谱分析，我们确定了一个β-同步的大规模网络，将中心前区域和后中性区域连接起来。然后，我们使用Granger因果关系来衡量记录位点之间的方向影响。在这两只猴子中，从原发性体感皮质到运动皮质和下壁皮层皮层的强烈granger因果影响都均观察到，后者区域也对运动皮层施加了granger因果影响。但是，从运动皮层到中心部位的Granger因果影响在一只猴子中很弱，在另一只猴子中没有观察到。据我们所知，这些结果首先证明了在运动维持行为期间同步的ββ振荡将多个感觉运动区域结合到大型网络中，并从原发性的体感和下层层顶皮质皮质皮质造成的Granger因果关系与运动皮质伴随。
Previous studies have shown that synchronized beta frequency (14-30 Hz) oscillations in the primary motor cortex are involved in maintaining steady contractions of contralateral arm and hand muscles. However, little is known about the role of postcentral cortical areas in motor maintenance and their patterns of interaction with motor cortex. We investigated the functional relations of beta-synchronized neuronal assemblies in pre- and postcentral areas of two monkeys as they pressed a hand lever during the wait period of a visual discrimination task. By using power and coherence spectral analysis, we identified a beta-synchronized large-scale network linking pre- and postcentral areas. We then used Granger causality spectra to measure directional influences among recording sites. In both monkeys, strong Granger causal influences were observed from primary somatosensory cortex to both motor cortex and inferior posterior parietal cortex, with the latter area also exerting Granger causal influences on motor cortex. Granger causal influences from motor cortex to postcentral sites, however, were weak in one monkey and not observed in the other. These results are the first, to our knowledge, to demonstrate in awake monkeys that synchronized beta oscillations bind multiple sensorimotor areas into a large-scale network during motor maintenance behavior and carry Granger causal influences from primary somatosensory and inferior posterior parietal cortices to motor cortex.