Validation of the 7-Minute Screen for the detection of early-stage Alzheimer's disease
Validation of the 7-Minute Screen for the detection of early-stage Alzheimer's disease
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DOI：
10.1159/000115972
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Gondo, Yasuyuki
中科院分区：
文献类型：
--
作者：
Ijuin, Mutsuo;Homma, Akira;Gondo, Yasuyuki
背景/目的：7分钟屏幕(7ms)是一种筛查电池，用于识别阿尔茨海默病(AD)的高概率个体。7MS包括四个分测试(时间定向、增强线索回忆、时钟绘制和语言流利性)，每一个都测量认知的不同方面。本研究旨在检验7MS的预测效度，以区分早期AD患者和健康对照受试者。方法：对63例疑似或可能患有AD的患者和91例年龄、性别分布、受教育程度相近的社区老年人进行7MS(纸笔版)和其他筛查组的测试。所有患者的临床痴呆评分(CDR)为0.5-1，为早期阿尔茨海默病(AD)，所有参与者的老年抑郁量表(15项版)得分均小于6。结果：患者和对照组在所有四个分测验上的平均得分均有显著差异。用原始Logistic回归公式计算的7ms总分对早期AD的敏感性为90.5%，特异性为92.3%。相关分析表明，7MS与现有的标准认知筛查量表(如MMSE、HDS-R)具有较高的一致性效度。在相关分析和多元回归分析中，人口学因素(年龄、性别和教育程度)与对照组的7MS总分无显著关联。结论：7MS具有较高的敏感性和特异性。我们还发现，7ms不受人口学特征的影响。这些结果表明，7MS是一种有用的筛查工具，用于区分早期AD患者和正常个体。版权所有(C)2008 S.Karger AG，巴塞尔。
Background/Aims: The 7-Minute Screen (7MS) is a screening battery to identify individuals with a high probability of Alzheimer's disease (AD). The 7MS consists of four subtests (Temporal Orientation, Enhanced Cued Recall, Clock Drawing, and Verbal Fluency), each measuring a different aspect of cognition. The present study is designed to examine the predictive validity of the 7MS to distinguish between patients with early-stage AD and healthy control subjects. Methods: Sixty-three patients who were diagnosed as having probable or possible AD and 91 community-dwelling elderly individuals of comparable age, sex distribution, and education were administered the 7MS (paper-and-pencil version) and other screening batteries. All patients were rated Clinical Dementia Rating (CDR) 0.5-1, categorized as early-stage AD, and all participants obtained a score of less than 6 for the Geriatric Depression Scale (15-item version). Results: Mean scores for patients and controls on all the four subtests were significantly different. When using the total score of the 7MS, which was calculated by the original logistic regression formula based on all of the four subtests, the sensitivity for early-stage AD was 90.5% with a specificity of 92.3%. Correlation analysis indicated high concurrent validity between the 7MS and existing standard cognitive screening batteries (e. g., MMSE, HDS-R). In correlation analysis and multiple regression analysis, demographic effects (age, sex, and education) were not significantly associated with the total score of the 7MS in controls. Conclusions: The results showed that the 7MS had a high level of sensitivity and specificity. We also found that the 7MS was not affected by demographic characteristics. These findings demonstrated that the 7MS is a useful screening tool for discriminating patients with early-stage AD from intact individuals. Copyright (c) 2008 S. Karger AG, Basel.