THE ORIGIN OF GENETIC INFORMATION - VIRUSES AS MODELS
THE ORIGIN OF GENETIC INFORMATION - VIRUSES AS MODELS
复制标题
DOI：
10.1016/0378-1119(93)90047-7
复制
发表时间：
1993-12-15
期刊：
影响因子：
3.5
通讯作者：
EIGEN, M
中科院分区：
文献类型：
--
作者：
EIGEN, M
生物体可以被描述为一个复杂的适应系统，它不同于任何复杂的化学结构，因为它具有基于信息处理的功能性自组织能力。如果有人问，这些信息从何而来，它的主要语义是什么，答案是：信息通过复制和选择在反馈回路中自我生成，目标是“生存或死亡”。本文描述了信息生成系统的理论框架，并为一些基本的遗传组织形式，如分子准物种，超循环和区室化RNA-蛋白质组装体提供了实验线索。这些结果主要是用RNA病毒和病毒样系统获得的。这些实验是在被称为“进化机器”的自动化、计算机控制的生物反应器的帮助下进行的，这可能构成新的“进化生物技术”的基础。
A living entity can be described as a complex adaptive system which differs from any, however complex, chemical structure by its capability of functional self-organization based on the processing of information. If one asks, where does this information come from and what is its primary semantics, the answer is: information generates itself in feedback loops via replication and selection, the objective being 'to be or not to be'. This paper describes the theoretical framework of information-generating systems and provides experimental clues for some basic forms of genetic organization, such as molecular quasi-species, hypercyclic and compartmentalized RNA-protein assemblies. The results are primarily obtained with RNA viruses and virus-like systems. The experiments are carried out with the help of automated, computer-controlled bioreactors, called 'evolution machines', that may form the basis of a new 'evolutionary biotechnology'.