Mesenchymal Stem Cell Homing Capacity
Mesenchymal Stem Cell Homing Capacity
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DOI：
10.1097/tp.0b013e3181a28533
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发表时间：
2009-05-15
期刊：
影响因子：
6.2
通讯作者：
Sordi, Valeria
中科院分区：
文献类型：
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作者：
Sordi, Valeria
间充质干细胞（Mesenchymal stem cells，MSCs）是骨髓的基质成分，是目前最有希望的组织再生和修复的前景。骨髓间充质干细胞很容易从骨髓中获得，具有分化成几种细胞类型的潜力，并显示出免疫调节特性。MSC用于细胞疗法的使用依赖于这些细胞归巢并长期移植到适当的靶组织中的能力。在过去的十年中，MSC归巢到BM和其他器官的能力已被报道。虽然MSC被募集到组织并穿过内皮细胞层的机制尚未完全了解，但可能涉及趋化因子及其受体，因为它们是已知控制细胞迁移的重要因素。例如，CXCR 4-CXCL 12和CX 3CR 1-CX 3CL 1轴驱动MSC和胰岛之间的串扰。
Mesenchymal stem cells (MSCs) are the stromal component of bone marrow (BM) and, at the moment, the most promising prospect for tissue regeneration and repair. MSCs are easily obtained from BM, have the potential to differentiate into several cell types, and show immunomodulatory properties. The use of MSCs for cell therapies relies on the capacity of these cells to home and engraft long term into the appropriate target tissue. During the past decade, MSC homing capacity to BM and other organs has been reported. Although the mechanisms by which MSCs are recruited to tissues and cross the endothelial cell layer are not yet fully understood, it is probable that chemokines and their receptors are involved, as they are important factors known to control cell migration. The CXCR4-CXCL12 and CX3CR1-CX3CL1 axes, for instance, drive the crosstalk between MSCs and pancreatic islets.