Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
复制标题
DOI：
10.1016/j.neulet.2004.03.042
复制
发表时间：
2004-06-03
影响因子：
2.5
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Chen, HH;Nicoletti, MA;Soares, JC
在成人双相情感障碍患者中报告了左侧上级颞回（STG）的abduction。然而，目前尚不清楚这种异常是否已经存在于这种疾病的早期。对16名DSM-IV儿童和青少年双相情感障碍患者（平均年龄+/- SD 15.5 +/- 3.4岁）和21名健康对照者（平均年龄+/- SD 16.9 +/- 3.8岁）进行了STG的磁共振成像（MRI）形态测量学分析。受试者接受了3D扰相梯度回忆采集MRI检查。使用以年龄、性别和颅内脑体积作为协变量的协方差分析，我们发现双相情感障碍患者的左侧总STG体积（12.5 +/- 1.5 cm（3））显著小于健康对照组（13.6 +/- 2.5 cm（3））（F = 4.45，d.f. = 1，32，P = 0.04）。双相情感障碍患者的左右STG白色物质体积显著较小可解释这种差异。白色连接减少可能是STG异常的核心，STG是言语、语言和交流的重要区域，可能是双相情感障碍患者神经认知缺陷的基础。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Abnormalities in left superior temporal gyrus (STG) have been reported in adult bipolar patients. However, it is not known whether such abnormalities are already present early in the course of this illness. Magnetic resonance imaging (MRI) morphometric analysis of STG was performed in 16 DSM-IV children and adolescents with bipolar disorder (mean age +/- SD 15.5 +/- 3.4 years) and 21 healthy controls (mean age +/- SD 16.9 +/- 3.8 years). Subjects underwent a 3D spoiled gradient recalled acquisition MRI examination. Using analysis of covariance with age, gender and intra-cranial brain volume as covariates, we found significantly smaller left total STG volumes in bipolar patients (12.5 +/- 1.5 cm(3)) compared with healthy controls (13.6 +/- 2.5 cm(3)) (F = 4.45, d.f. = 1, 32, P = 0.04). This difference was accounted for by significantly smaller left and right STG white matter volumes in bipolar patients. Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients. (C) 2004 Elsevier Ireland Ltd. All rights reserved.