Wnt/beta-catenin signaling in development and disease.
Wnt/beta-catenin signaling in development and disease.
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作者：
H. Clevers
在过去的二十年中，一项引人注目的跨学科努力揭示了WNT（无翼和INT-1）信号转导级联。Wnt基因编码存在于所有动物基因组中的小分泌蛋白。Wnt信号几乎参与了胚胎发育的各个方面，也控制着许多成年组织的稳态自我更新。Wnt通路的种系突变导致几种遗传性疾病，体细胞突变与肠癌和多种其他组织的癌症有关。
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.