The effect of ofloxacin on experimental periodontitis in hamsters infected with Actinomyces viscosus ATCC 15987.
The effect of ofloxacin on experimental periodontitis in hamsters infected with Actinomyces viscosus ATCC 15987.
复制标题
氧氟沙星对感染粘性放线菌 ATCC 15987 的仓鼠实验性牙周炎的影响。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
H. Suginaka
中科院分区：
文献类型：
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作者：
S. Kametaka;T. Miyazaki;Y. Inoue;S. Hayashi;A. Takamori;Y. Miyake;H. Suginaka
采用粘放线菌ATCC 15987口腔接种法感染叙利亚仓鼠，诱导实验性牙周炎。研究了抗生素氧氟沙星（OFLX）对实验性牙周炎的影响。A组在接种细菌后2周，每日将OFLX凝胶涂于牙龈黏膜。B组和C组分别为感染对照组和未感染对照组。这三组仓鼠喂食高糖粉末状食物。D组的仓鼠，也是未感染的仓鼠，被喂食普通的固体食物。感染后11周进行唾液潜血检查、牙龈指数及菌斑指数评估、牙槽骨流失测量、细菌检查及组织学观察。与未感染的对照组相比，B组的牙龈指数、菌斑指数和牙槽骨丢失水平明显更高。b组患者出现严重的牙龈炎症，牙龈袋形成，许多炎症细胞迁移，骨质流失明显。而A组患者在使用OFLX治疗后，这些炎症变化较轻。
Syrian hamsters were infected with Actinomyces viscosus ATCC 15987 by inoculation into the oral cavity to induce experimental periodontitis. The effect of an antibiotic, ofloxacin (OFLX), on the experimental periodontitis was examined. In Group A, OFLX gel was applied daily to the gingival mucosa, 2 weeks after bacterial inoculation. Groups B and C were an infected control and a noninfected control, respectively. The hamsters in these three groups were fed a powdered high-sucrose diet. The hamsters in Group D, also a noninfected group, were fed an ordinary solid diet. Salivary occult blood test, evaluation of gingival and plaque index, measurement of alveolar bone loss, bacterial examination, and histological observation were performed 11 weeks after infection. Group B exhibited significantly higher levels of gingival index, plaque index, and alveolar bone loss than the noninfected controls. Severe inflammation of the gingivae, formation of gingival pockets, migration of many inflammatory cells, and obvious bone loss were also observed in Group B. However, these inflammatory changes were milder in Group A, which was treated with OFLX.