UROPATHOGENICITY IN RATS AND MICE OF PROVIDENCIA STUARTII FROM LONG-TERM CATHETERIZED PATIENTS
UROPATHOGENICITY IN RATS AND MICE OF PROVIDENCIA STUARTII FROM LONG-TERM CATHETERIZED PATIENTS
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DOI：
10.1016/s0022-5347(17)43287-3
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发表时间：
1987-09-01
影响因子：
6.6
通讯作者：
WARREN, JW
中科院分区：
文献类型：
--
作者：
JOHNSON, DE;LOCKATELL, CV;WARREN, JW
斯氏普罗威登斯菌是一种常见且持续存在于长期留置导尿的老年患者尿路的分离株，具有多重抗生素耐药性，可能导致这些患者的胎儿菌血症。我们研究了大鼠和小鼠中的斯氏疟原虫菌株，以确定尿路致病性的差异。所研究的菌株在有助于其他细菌物种的致病性的因子的表达方面各不相同。用斯氏毕赤酵母菌株HO（表达的因子）攻毒后的尿路反应与报告的尿路致病性大肠杆菌反应相似。大肠杆菌菌株的细菌持久性和组织学变化。在用斯氏毕赤酵母RO菌株进行类似攻击的动物中（未表达因子），反应与非尿路致病性大肠杆菌报告的反应相似。大肠杆菌菌株。结果表明：1）动物模型研究可用于基于尿路致病性区分斯氏毕赤酵母菌株，B）斯氏毕赤酵母尿路致病性可能与其他物种中与毒力相关的可识别因子相关，以及c）CBA小鼠模型似乎最适合于斯氏毕赤酵母尿路致病性的研究。
Providencia stuartii, a frequent and persistent isolate from the urinary tract of chronically catheterized elderly patients, is multiply antibiotic resistant and may cause fetal bacteremia in those patients. We studied P. stuartii strains in rats and mice to determine differences in uropathogenicity. Strains studied varied in expression of factors which contribute to pathogenicity of other bacterial species. Urinary tract responses following challenge with P. stuartii strain HO (factors expressed) were similar to responses reported for uropathogenic E. coli strains both in bacterial persistence and histologic change. In animals similarly challenged with P. stuartii strain RO (factors not expressed), responses were similar to those reported for non-uropathogenic E. coli strains. Results indicate that: 1) animal model studies may be useful in differentiating P. stuartii strains based on uropathogenicity, b) P. stuartii uropathogenicity may be related to identifiable factors associated with virulence in other species, and c) the CBA mouse model appears to be the most suitable for studies of P. stuartii uropathogenicity.