Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women
Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women
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DOI：
10.1007/s00198-012-1973-2
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发表时间：
2013-02-01
影响因子：
4
通讯作者：
Lanham-New, S. A.
中科院分区：
文献类型：
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作者：
Darling, A. L.;Hart, K. H.;Lanham-New, S. A.
这是第一项为期一年的纵向研究，旨在评估居住在英国的年轻南亚女性的维生素D缺乏症。研究结果表明，维生素D缺乏症在这群女性中极为普遍，而且全年都存在，这是一个重大的公共健康问题。目前缺乏评估生活在北纬地区的年轻南亚妇女维生素D水平季节性变化的纵向数据。对绝经后南亚妇女的研究表明，25-羟基维生素D [25(OH)D]缺乏季节性变化，尽管尚不清楚这在绝经前南亚妇女中是否普遍存在。我们的目的是纵向评估25(OH)D的季节性变化和年轻居住在英国的南亚女性与白种人相比维生素D缺乏症的患病率。我们还旨在确定膳食维生素D和阳光照射在解释血清25(OH)D方面的相对贡献。这是一项为期1年的前瞻性队列研究，评估了居住在英国萨里（北纬51A度）、年龄在20-55岁的南亚（n = 35）和高加索（n = 105）绝经前妇女。主要观察指标为血清25(OH)D浓度。次要结果是血清甲状旁腺激素、自我报告的膳食维生素D摄入量和个人剂量测定的UVB暴露。南亚地区25(OH)D < 25 nmol/L的人群主要集中在冬季（81%）和秋季（79.2%）。缺乏状态（低于50 nmol/L）在高加索女性中很常见。多层次模型表明，与阳光照射相比（1.59,95% CI = 0.83-2.35），膳食摄入维生素D对25(OH)D水平没有影响（-0.08,95% CI = -1.39至1.23）。南亚女性全年缺乏维生素D的现象极为普遍。这些发现对怀孕期间维生素D缺乏的不良影响构成了巨大的健康威胁，需要紧急的维生素D公共卫生政策和行动。
This is the first 1-year longitudinal study which assesses vitamin D deficiency in young UK-dwelling South Asian women. The findings are that vitamin D deficiency is extremely common in this group of women and that it persists all year around, representing a significant public health concern.There is a lack of longitudinal data assessing seasonal variation in vitamin D status in young South Asian women living in northern latitudes. Studies of postmenopausal South Asian women suggest a lack of seasonal change in 25-hydroxy vitamin D [25(OH)D], although it is unclear whether this is prevalent among premenopausal South Asians. We aimed to evaluate, longitudinally, seasonal changes in 25(OH)D and prevalence of vitamin D deficiency in young UK-dwelling South Asian women as compared with Caucasians. We also aimed to establish the relative contributions of dietary vitamin D and sun exposure in explaining serum 25(OH)D.This is a 1-year prospective cohort study assessing South Asian (n = 35) and Caucasian (n = 105) premenopausal women living in Surrey, UK (51A degrees N), aged 20-55 years. The main outcome measured was serum 25(OH)D concentration. Secondary outcomes were serum parathyroid hormone, self-reported dietary vitamin D intake and UVB exposure by personal dosimetry.Serum 25(OH)D < 25 nmol/L was highly prevalent in South Asians in the winter (81 %) and autumn (79.2 %). Deficient status (below 50 nmol/L) was common in Caucasian women. Multi-level modelling suggested that, in comparison to sun exposure (1.59, 95 %CI = 0.83-2.35), dietary intake of vitamin D had no impact on 25(OH)D levels (-0.08, 95 %CI = -1.39 to 1.23).Year-round vitamin D deficiency was extremely common in South Asian women. These findings pose great health threats regarding the adverse effects of vitamin D deficiency in pregnancy and warrant urgent vitamin D public health policy and action.