The Utilization of Urolithin A—A Natural Polyphenol Metabolite of Ellagitannins as a Modulator of the Gut Microbiota for Its Potential Use in Obesity Therapy
The Utilization of Urolithin A—A Natural Polyphenol Metabolite of Ellagitannins as a Modulator of the Gut Microbiota for Its Potential Use in Obesity Therapy
复制标题
利用尿石素 A（鞣花单宁的天然多酚代谢物）作为肠道微生物群的调节剂，在肥胖治疗中具有潜在用途
DOI：
10.3390/iecbm2020-08806
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
M. I. Khan
中科院分区：
文献类型：
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作者：
Abdulrasheed O Abdulrahman;M. Alzubaidi;M. Nadeem;J. Khan;I. Rather;M. I. Khan
肥胖是一个全球性的健康问题，与肠道微生物组成的生态失调有关。本研究旨在研究尿石素A（Uro-A）通过调节肠道微生物群减少体重增加的潜力。给大鼠喂食高脂饮食并给予Uro-A。使用16 S rDNA基因测序分析肠道微生物群落组成的变化。我们的研究结果表明，Uro-A显着降低体重增加，并调节肠道微生物的组成，这些微生物与体重，炎症，葡萄糖受损和脂质代谢功能障碍有关，这些都与肥胖有关。
Obesity, a global health concern, is associated with the dysbiosis of intestinal microbial composition. This study aims to investigate the potential of urolithin A (Uro-A) in reducing body weight gain through modulation of the gut microbiota. Rats were fed a high-fat diet and administered with Uro-A. Changes in the composition of the gut microbial community were analyzed using 16S rDNA gene sequencing. Our results showed that Uro-A significantly decreased body weight gain and modulated the compositions of gut microbes that are related to body weight, inflammation, impaired glucose, and dysfunctional lipid metabolism, which are all associated with obesity.