Antigen-specific immunotherapy for autoimmune diseases
Antigen-specific immunotherapy for autoimmune diseases
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DOI：
10.1517/14712598.7.3.359
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发表时间：
2007-02
影响因子：
4.6
通讯作者：
Kazuhiko Yamamoto;A. Okamoto;K. Fujio
中科院分区：
文献类型：
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作者：
Kazuhiko Yamamoto;A. Okamoto;K. Fujio
自身免疫性疾病的治疗现状并不令人满意。抗原特异性免疫疗法具有作为未来疗法的潜力，可以提供最大的疗效和最小的不良反应。已经进行了几项抗原特异性免疫疗法的试验，但到目前为止还没有明确的方向。关于免疫系统中的抗原特异性，T细胞是必不可少的组成部分。然而，目前，我们没有足够的策略来操纵抗原特异性T细胞。在这篇综述中，作者提出T细胞受体基因转移可用于抗原特异性免疫治疗。在所提出的技术中，将首先鉴定患者中重要的疾病相关的并且因此是抗原特异性的T细胞，然后将从这些单个T细胞中分离编码α和β T细胞受体的一对cDNA。然后这些基因将被转移到自身淋巴细胞中。这些工程化的抗原特异性细胞也可以被操纵以表达适当的功能基因，然后可以应用于特异性免疫疗法。
The status of autoimmune disease therapies is not satisfactory. Antigen-specific immunotherapy has potential as a future therapy that could deliver maximal efficacy with minimal adverse effects. Several trials of antigen-specific immunotherapy have been performed, but so far no clear directions have been established. With regard to antigen-specificity in the immune system, T cells are essential components. However, at present, we do not have a sufficient range of strategies for manipulating antigen-specific T cells. In this review, the authors propose that T cell receptor gene transfer could be used for antigen-specific immunotherapy. In the proposed technique, important disease-related and, thus, antigen-specific T cells in patients would first be identified, and then a pair of cDNAs encoding α and β T cell receptors would be isolated from these single T cells. These genes would then be transferred into self lymphocytes. These engineered antigen-specific cells can also be manipulated to express appropriate functional genes that could then be applied to specific immunotherapy.