Aminoquinoline-anchored polynorbornene for sequential fluorescent sensing of Zn2+ and ATP
Aminoquinoline-anchored polynorbornene for sequential fluorescent sensing of Zn2+ and ATP
复制标题
氨基喹啉锚定聚降冰片烯用于 Zn2 和 ATP 的连续荧光传感
DOI：
10.1016/j.saa.2021.120771
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xie Yu
中科院分区：
文献类型：
--
作者：
Chen Gui-Yan;Wan Wen;Cao Qian-Yong;Xie Yu
设计并合成了一种新型氨基喹啉功能化降冰片烯(1)及其开环复分解聚合(ROMP)共聚物P1。聚合物探针P1可以在水溶液中自组装纳米聚集体。荧光实验表明，在Tris-HCl缓冲溶液中，1和P1对Zn2+均表现出相对于其他金属离子的比例荧光响应，其中聚合物探针P1比小分子探针1表现出更好的光稳定性和更高的结合亲和力。此外，原位形成的P1-Zn2+整体被成功地用作ATP的辅助传感器。P1还成功地用于监测活细胞中的细胞内Zn2+和ATP。
A novel aminoquinoline functionalized norbornene (1) and its ring-opening metathesis polymerization (ROMP) copolymerP1have been designed and synthesized. The polymer probeP1can self-assemble nano aggregation in aqueous solution. The fluorescent experiments revealed that both1andP1show a ratiometric fluorescence response toward Zn2+over other mental ions in Tris-HCl buffer solution, with the polymer probeP1shows a better photostability and higher binding affinity than that of the small molecular probe1. Furthermore, thein situformedP1-Zn2+ensemble was successfully used as the secondary sensor for ATP.P1is also successfully used for monitoring intracellular Zn2+and ATP in living cells.