The cell surface receptor SLAM controls T cell and macrophage functions.
The cell surface receptor SLAM controls T cell and macrophage functions.
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细胞表面受体 SLAM 控制 T 细胞和巨噬细胞的功能。
DOI：
10.1084/jem.20031835
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发表时间：
2004-05-03
影响因子：
15.3
通讯作者：
Terhorst, C
中科院分区：
文献类型：
--
作者：
Wang, NH;Satoskar, A;Faubion, W;Howie, D;Okamoto, S;Feske, S;Gullo, C;Clarke, K;Sosa, MR;Sharpe, AH;Terhorst, C
信号淋巴细胞激活分子（SLAM）是一种在活化淋巴细胞和抗原呈递细胞上表达的糖蛋白，已被证明是抗原驱动的T细胞应答的共调节因子，并且是麻疹病毒的两种受体之一。在此我们表明，SLAM - / - CD4 +细胞中T细胞受体诱导的白细胞介素（IL） - 4分泌下调，而CD4 + T细胞产生的干扰素γ仅略微上调。尽管SLAM控制巨噬细胞对脂多糖（LPS）应答时IL - 12、肿瘤坏死因子和一氧化氮的产生，但SLAM不调节吞噬作用以及对肽聚糖或CpG的应答。因此，SLAM作为一种共受体，调节小鼠巨噬细胞表面主要LPS受体Toll样受体4所转导的信号。巨噬细胞功能缺陷导致SLAM - / - C57Bl / 6小鼠无法清除利什曼原虫。我们得出结论，共受体SLAM在获得性免疫应答和先天性免疫应答的界面上起着核心作用。
Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor–induced interleukin (IL)-4 secretion by SLAM−/− CD4+ cells is down-regulated, whereas interferon γ production by CD4+ T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor that regulates signals transduced by the major LPS receptor Toll-like receptor 4 on the surface of mouse macrophages. A defective macrophage function resulted in an inability of SLAM−/− C57Bl/6 mice to remove the parasite Leishmania major. We conclude that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.
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