A model for transcutaneous current stimulation: simulations and experiments
A model for transcutaneous current stimulation: simulations and experiments
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DOI：
10.1007/s11517-008-0422-z
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发表时间：
2009-03-01
影响因子：
3.2
通讯作者：
Morari, Manfred
中科院分区：
文献类型：
--
作者：
Kuhn, Andreas;Keller, Thierry;Morari, Manfred
已经开发了复杂神经模型用于描述人类动作电位的产生。这种神经模型主要用于对可植入电刺激系统进行建模，其中刺激电极靠近神经（近场）。为了解决这些神经模型是否也可以用于模拟经皮电刺激（TES）（远场），我们已经开发了一个TES模型，包括体积导体和不同的先前公布的非线性神经模型。体积导体对电极、电极-皮肤界面、皮肤、脂肪、肌肉和骨骼的电阻和电容特性进行建模。使用非线性神经模型从体积导体内的电位场得出神经激活的结论。比较模拟和实验测量的时值值（神经兴奋性的衡量标准）和对人类志愿者的肌肉抽搐力，我们可以得出结论，一些已发表的神经模型可以用于TES模型。所提出的TES模型为TES的更广泛的模型实现提供了第一步，其中例如，可以测试多阵列电极配置。
Complex nerve models have been developed for describing the generation of action potentials in humans. Such nerve models have primarily been used to model implantable electrical stimulation systems, where the stimulation electrodes are close to the nerve (near-field). To address if these nerve models can also be used to model transcutaneous electrical stimulation (TES) (far-field), we have developed a TES model that comprises a volume conductor and different previously published non-linear nerve models. The volume conductor models the resistive and capacitive properties of electrodes, electrode-skin interface, skin, fat, muscle, and bone. The non-linear nerve models were used to conclude from the potential field within the volume conductor on nerve activation. A comparison of simulated and experimentally measured chronaxie values (a measure for the excitability of nerves) and muscle twitch forces on human volunteers allowed us to conclude that some of the published nerve models can be used in TES models. The presented TES model provides a first step to more extensive model implementations for TES in which e.g., multi-array electrode configurations can be tested.