N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
N-Domain Isoform of Angiotensin I Converting Enzyme as a Marker of Hypertension: Populational Study
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DOI：
10.1155/2012/581780
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发表时间：
2012-01-01
影响因子：
1.9
通讯作者：
Casarini, Dulce E.
中科院分区：
文献类型：
--
作者：
Maluf-Meiken, Leila C. V.;Fernandes, Fernanda B.;Casarini, Dulce E.
本文的目的是调查来自巴西维托里亚的一组人群中尿液90 kDa N-结构域ACE的存在，以验证其与原发性高血压的相关性，因为该亚型可能是高血压的可能遗传标记。对1150名受试者的人体测量、临床和实验室参数进行了评价，并测量了血压（BP）。根据尿液中的ACE亚型，将研究人群分为：ACE 65/90/190，存在三种ACE亚型（n = 795），ACE 90（+）（65/90）（n = 186）和ACE 90（-）（65/190）（n = 169），基于90 kDa ACE亚型的存在（+）或不存在（-）。ACE 90（+）组的人体测量参数、血脂、血清尿酸、血糖水平以及收缩压和舒张压均显著高于ACE 90（-）组和ACE 65/90/190组。我们发现，98%的ACE 90（+）组和38%的ACE 65/90/190组的个体患有高血压，而ACE 90-组中只有1%的高血压个体。有一个高的存在90 kDa的N-域ACE亚型（85%）的研究人群。具有三种亚型的正常血压受试者的百分位数为62%。我们的研究结果有助于开发新的有效的策略来预防和治疗高血压，以避免心血管疾病的发展。
The aim of this paper was to investigate the presence of the urinary 90 kDa N-domain ACE in a cohort of the population from Vitoria, Brazil, to verify its association with essential hypertension since this isoform could be a possible genetic marker of hypertension. Anthropometric, clinical, and laboratory parameters of the individuals were evaluated (n = 1150) and the blood pressure (BP) was measured. The study population was divided according to ACE isoforms in urine as follows: ACE 65/90/190, presence of three ACE isoforms (n = 795), ACE 90(+) (65/90) (n = 186), and ACE 90(-) (65/190) (n = 169) based on the presence (+) or absence (-) of the 90 kDa ACE isoform. The anthropometric parameters, lipid profile, serum levels of uric acid, glucose, and the systolic and diastolic BP were significantly greater in the ACE 90(+) compared with the ACE 90(-) and ACE 65/90/190 individuals. We found that 98% of individuals from the ACE 90(+) group and 38% from the ACE 65/90/190 group had hypertension, compared to only 1% hypertensive individuals in the ACE 90- group. There is a high presence of the 90 kDa N-domain ACE isoform (85%) in the studied population. The percentile of normotensive subjects with three isoforms was 62%. Our findings could contribute to the development of new efficient strategy to prevent and treat hypertension to avoid the development of cardiovascular disease.