Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures
Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures
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成年大鼠早期复杂性热性惊厥后获得性惊厥易感性的性别差异
DOI：
10.1007/s12264-014-1482-8
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发表时间：
2014-12-01
影响因子：
5.6
通讯作者：
Chen, Zhong
中科院分区：
文献类型：
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作者：
Dai, Yun-Jian;Xu, Zheng-Hao;Chen, Zhong
性别差异与包括癫痫在内的许多神经疾病有关。然而，关于性别差异对具有特定早期病理状态的成年人癫痫风险的影响，如婴儿时期的复杂热性癫痫(FSS)，人们知之甚少。在本实验中，我们采用了一种成熟的大鼠复杂FS模型，结果表明：(1)雌性和雄性幼鼠对高温、戊四氮(PTZ)和最大电休克(MES)诱发惊厥的敏感性相似，而正常成年大鼠雄性对PTZ和MES诱发癫痫的敏感性高于年龄匹配的雌性；(2)幼年复杂FSS的成年大鼠比正常大鼠获得更高的癫痫敏感性，重要的是，雌性FS大鼠比雄性FS大鼠对PTZ和MES更敏感；(3)与癫痫易感性相关的炎性因子IL-1β的蛋白表达在成年FS女性高于男性，这可能反映了癫痫易感性的性别差异现象。我们的结果提供了直接证据，表明复杂的FSS后的获得性癫痫敏感性是性别相关的。
Gender differences are involved in many neurological disorders including epilepsy. However, little is known about the effect of gender difference on the risk of epilepsy in adults with a specific early pathological state such as complex febrile seizures (FSs) in infancy. Here we used a well-established complex FS model in rats and showed that: (1) the susceptibility to seizures induced by hyperthermia, pentylenetetrazol (PTZ), and maximal electroshock (MES) was similar in male and female rat pups, while males were more susceptible to PTZ- and MES-induced seizures than age-matched females in normal adult rats; (2) adult rats with complex FSs in infancy acquired higher seizure susceptibility than normal rats; importantly, female FS rats were more susceptible to PTZ and MES than male FS rats; and (3) the protein expression of interleukin-1β, an inflammatory factor associated with seizure susceptibility, was higher in adult FS females than in males, which may reflect a gender-difference phenomenon of seizure susceptibility. Our results provide direct evidence that the acquired seizure susceptibility after complex FSs is gender-dependent.