Safe Generation and Direct Use of Diazoesters in Flow Chemistry
Safe Generation and Direct Use of Diazoesters in Flow Chemistry
复制标题
流动化学中重氮酯的安全生成和直接使用
作者：
Simon T. R. Müller;Daniel J. Smith;Paul C. Hellier;T. Wirth
介绍了一种安全、快速的连续流工艺生产β-羟基-α-重氮酯的方法。该合成包括原位形成重氮乙酸乙酯，并在两步连续流微反应器装置中加入几种醛。乙酸铑催化随后的1,2-氢化物转移，在三步序列中获得β-酮酯。
Abstract A safe and fast method for the production of β-hydroxy-α-diazoesters in continuous flow technology is described. The synthesis involves the formation of ethyl diazoacetate in situ and the addition to several aldehydes in a two-step continuous flow microreactor setup. Rhodium acetate catalyzes a subsequent 1,2-hydride shift to give access to β-keto esters in a three-step sequence.