Estimating genetic and non-genetic components of variance for fasting glucose levels in pedigrees ascertained through non-insulin dependent diabetes.
Estimating genetic and non-genetic components of variance for fasting glucose levels in pedigrees ascertained through non-insulin dependent diabetes.
复制标题
估计通过非胰岛素依赖型糖尿病确定的家系中空腹血糖水平变异的遗传和非遗传成分。
DOI：
10.1111/j.1469-1809.1982.tb01586.x
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发表时间：
1982
影响因子：
1.9
通讯作者：
Fajans,SS
中科院分区：
文献类型：
--
作者：
Beaty,TH;Fajans,SS
通过非胰岛素依赖型糖尿病先证者确定的14个家系中337名个体的空腹血糖水平，用于估计多因素遗传模型下的遗传和非遗传方差分量。在该样本中，遗传因素在控制基础碳水化合物代谢的变化方面很重要，如年龄校正的空腹血糖对数所示。没有证据表明任意同胞共同环境或任意父母共同环境占这些数据中空腹血糖变异性的显著部分。一个任意的环境共享的父母和后代，然而，有一个轻微的显着影响的可能性。从多因子模型以这种方式分析得到的参数估计是敏感的极端表型值，但是，必须谨慎估计总的遗传变异。虽然加性遗传因素确实占空腹血糖总变异的很大比例，但很大一部分仍然无法解释。
Fasting glucose levels measured on 337 individuals in 14 pedigrees ascertained through a proband with non‐inuslin dependent diabetes were used to estimate genetic and non‐genetic components of variance under a multifactorial model of inheritance. In this sample genetic factors were important in controlling variation in basal carbohydrate metabolism, as represented by age‐adjusted log‐fasting glucose. There was no evidence that arbitrary sib common environments or arbitrary parent common environments accounted for significant portions of the variability in fasting glucose in these data. An arbitrary environment shared by parent and offspring, however, had a marginally significant impact on the likelihood.Parameter estimates obtained from multifactorial models analysed in this manner are sensitive to extreme phenotypic values, however, and caution must be exerciese in estimating total genetic variation. While additive genetic factors did account for a significant proportion of the total variation in fasting glucose, a large proportion remained unexplained.