Hemispheric surface area: Sex, laterality and age effects
Hemispheric surface area: Sex, laterality and age effects
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DOI：
10.1093/cercor/13.4.364
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发表时间：
2003-04-01
期刊：
影响因子：
3.7
通讯作者：
Dazzan, P
中科院分区：
文献类型：
--
作者：
Barta, P;Dazzan, P
皮质的表面积在理论上是重要的，但比皮质体积更复杂。其理论上的重要性主要是由于任何区域的皮层表面积（而不是体积）与该区域的神经元数量之间的密切关系。人类大脑皮层的表面是高度复杂的，这给测量其表面积带来了困难。我们在这里报告一个简单的扩展体视学方法的磁共振图像，是简单，高效和优雅。我们研究了该方法的可靠性和测量误差与生物变异的关系，并提出了一种简单的方法，使用方差分量分析，量化所有相关参数的有效设计的实验。我们采用这种方法的一个小样本的15个健康的年轻男性受试者，分别匹配的年龄和父母的社会经济地位，以15个健康的女性受试者，并测量大脑半球的表面积。我们在这项小型研究中没有发现性别差异或不对称的证据，不像以前使用死后材料的报告。
The surface area of the cortex is theoretically important but more complicated to measure than cortical volume. Its theoretical importance is primarily due to a close relationship between the surface area (not the volume) of the cortex at any region and the number of neurons in that region. The surface of the cortex in humans is highly convoluted and this creates difficulties in measuring its surface area. We report here on a straightforward extension of stereologic methods to magnetic resonance images that is simple, efficient and elegant. We studied the method's reliability and the relationship of measurement error to biological variation and suggest a simple method, using variance components analysis, for quantifying all the relevant parameters for efficient design of experiments. We applied this method to a small sample of 15 healthy young male subjects, matched individually on age and parental socioeconomic status to 15 healthy female subjects and measured the surface areas of both cerebral hemispheres. We found no evidence for gender differences or asymmetry in this small study, unlike a previous report using post-mortem material.