Guaiane-Type Sesquiterpenes from Curcuma phaeocaulis and Their Inhibitory Effects on Nitric Oxide Production
Guaiane-Type Sesquiterpenes from Curcuma phaeocaulis and Their Inhibitory Effects on Nitric Oxide Production
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DOI：
10.1021/np400202f
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发表时间：
2013-06-01
影响因子：
5.1
通讯作者：
Qiu, Feng
中科院分区：
文献类型：
--
作者：
Liu, Yue;Ma, JiangHao;Qiu, Feng
从蓬莪术（Curcuma phaeocaulis）根茎中分离得到10种新的愈创木烷型倍半萜（1 - 10），即蓬莪术素A - J，以及18种已知的愈创木烷衍生物。它们的结构是在广泛的光谱分析、X射线晶体学分析以及与文献数据对比的基础上确定的。化合物10是从姜黄属（Curcuma）中分离出的具有这种不寻常骨架的降倍半萜的首个例子。所有分离得到的化合物都进行了对脂多糖（LPS）诱导的RAW 264.7巨噬细胞中一氧化氮产生的抑制活性测试。化合物1、2、20以及22 - 24对一氧化氮产生的抑制作用的半数抑制浓度（IC₅₀）值小于2 μM。对这些化合物的初步构效关系进行了讨论。
Ten new guaiane-type sesquiterpenes (1-10), phaeocaulisins A-J, and 18 known guaiane derivatives were isolated from rhizomes of Curcuma phaeocaulis. Their structures were established on the basis of extensive spectroscopic analyses, X-ray crystallographic analysis, and comparison with literature data Compound 10 is the first example of a norsesquiterpene with this unusual skeleton isolated from the genus Curcuma. All of the,isolate,compounds were tested for inhibitory activity against LPS-induced. nitric oxide production in RAW 264.7 macrophages. Compounds 1, 2, 20, and 22-24 inhibited nitric oxide production with IC50 values less than 2 mu M. Preliminary structure-activity relationships for foe. these compounds are discussed.