Infant and child growth and fatness and fat distribution in Guatemalan adults
Infant and child growth and fatness and fat distribution in Guatemalan adults
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DOI：
10.1093/oxfordjournals.aje.a009784
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发表时间：
1999-01-15
影响因子：
5
通讯作者：
Flores, R
中科院分区：
文献类型：
--
作者：
Schroeder, DG;Martorell, R;Flores, R
为了研究发展中国家子宫内或幼儿期生长不良是否与成人腹部肥胖有关，作者对 372 名危地马拉女性和 161 名男性危地马拉人的前瞻性数据进行了分析，这些数据在 1969 年至 1977 年期间作为儿童进行测量，并在 1988 年至 1989 年（男性和女性）和 1991 年至 1994 年（仅女性）作为成人重新测量。儿童期发育迟缓（年龄别身高 z 评分）与男性较低的体重指数和体脂百分比有关，而女性则没有发现任何关联。然而，一旦总体脂肪和混杂因素得到控制，无论男女，严重发育迟缓的儿童成人腹部脂肪（腰臀比）都显着增加。三岁时年龄别身高 z 得分每降低一个，成年腰臀比 (x100) 男性增加 0.65（95% 置信区间 0.10 至 1.20），女性增加 0.29（95% 置信区间 -0.03 至 0.61）。 迁移到城市中心与严重发育不良女性的腰臀比更大显着相关（p = 0.03）。在 137 名女性的子样本中，与长而瘦或矮而胖的新生儿或出生后发育不良的儿童相比，矮而瘦的新生儿成人腹部脂肪含量显着更高。出生体重每减少一公斤，成人腰臀比 (x100) 增加 1.58（95% 置信区间 0.35 至 2.81）。作者得出的结论是，在经济快速发展和城市移民同时存在孕产妇和儿童营养不良的国家，腹部肥胖和相关慢性疾病可能会增加。
To examine whether poor growth in utero or young childhood is associated with adult abdominal fatness in a developing country context, the authors analyzed prospectively collected data on 372 female and 161 male Guatemalans measured as children between 1969 and 1977 and remeasured as adults in 1988-1989 (men and women) and 1991-1994 (women only). Childhood stunting (height-for-age z score) was associated with a lower body mass index and percent body fat in men, while no associations were found in women. In both sexes, however, severely stunted children had significantly greater adult abdominal fatness (waist:hip ratio), once overall fatness and confounders were controlled. The adult waist:hip ratio (x100) was increased by 0.65 (95% confidence interval 0.10 to 1.20) in men and 0.29 (95% confidence interval -0.03 to 0.61) in women for each height-for-age z score less at age three, Migration to urban centers was significantly associated with an even greater waist:hip ratio in severely stunted females (p = 0.03). In a subsample of 137 women, short and thin newborns had significantly greater adult abdominal fatness compared with long and thin or short and fat newborns or children who became stunted postnatally. The adult waist:hip ratio (x100) was increased by 1.58 (95% confidence interval 0.35 to 2.81) for each kilogram less birth weight. The authors conclude that, in countries where maternal and child malnutrition exists alongside rapid economic development and urban migration, abdominal obesity and related chronic diseases are likely to increase.