Dysexecutive functioning in mild cognitive impairment: derailment in temporal gradients.
Dysexecutive functioning in mild cognitive impairment: derailment in temporal gradients.
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DOI：
10.1017/s1355617711001238
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发表时间：
2012-01
影响因子：
2.6
通讯作者：
Libon, David J.
中科院分区：
文献类型：
--
作者：
Eppig, Joel;Wambach, Denene;Nieves, Christine;Price, Catherine C.;Lamar, Melissa;Delano-Wood, Lisa;Giovannetti, Tania;Bettcher, Brianne M.;Penney, Dana L.;Swenson, Rod;Lippa, Carol;Kabasakalian, Anahid;Bondi, Mark W.;Libon, David J.
关键词：
提供了三种统计学确定的轻度认知障碍（MCI）患者群的证据：遗忘症（aMCI）、执行障碍（dMCI）和混合型（mxMCI）。目前的研究进一步研究了MCI中的执行障碍障碍，使用脱轨的时间梯度的框架，即随着时间或测试时期的推移，执行测试的性能下降。通过计算15秒时间段内总字母流畅性输出的斜率和韦氏记忆量表-精神控制子测试（波士顿修订版）的初始、中间和后期三重组的准确性指数，在操作上定义时间梯度。对于字母流畅性，与aMCI和NC组相比，dMCI组的斜率更陡。组间心理控制分析显示，与NC受试者相比，三联征1的dMCI表现更差。在三联征2中，dMCI评分低于aMCI和NC;在三联征3中，mxMCI表现差于NC。组内心理控制分析在aMCI和NC参与者的所有三合会中产生了相同的表现。与三联体2和三联体3相比，三联体1的mxMCI评分较低。dMCI参与者在三联征1上的表现也比三联征2和三联征3差，但在三联征3上的得分高于三联征2。这些数据表明，受损的时间梯度可以提供一个有用的启发式理解MCI的执行障碍。
provided evidence for three statistically determined clusters of patients with mild cognitive impairment (MCI): amnesic (aMCI), dysexecutive (dMCI), and mixed (mxMCI). The current study further examined dysexecutive impairment in MCI using the framework of derailed temporal gradients, that is, declining performance on executive tests over time or test epoch. Temporal gradients were operationally defined by calculating the slope of aggregate letter fluency output across 15-s epochs and accuracy indices for initial, middle, and latter triads from the Wechsler Memory Scale-Mental Control subtest (Boston Revision). For letter fluency, slope was steeper for dMCI compared to aMCI and NC groups. Between-group Mental Control analyses for triad 1 revealed worse dMCI performance than NC participants. On triad 2, dMCI scored lower than aMCI and NCs; on triad 3, mxMCI performed worse versus NCs. Within-group Mental Control analyses yielded equal performance across all triads for aMCI and NC participants. mxMCI scored lower on triad 1 compared to triads 2 and 3. dMCI participants also performed worse on triad 1 compared to triads 2 and 3, but scored higher on triad 3 versus triad 2. These data suggest impaired temporal gradients may provide a useful heuristic for understanding dysexecutive impairment in MCI.