Associations between health-related fitness and quality of life in newly diagnosed breast cancer patients.
Associations between health-related fitness and quality of life in newly diagnosed breast cancer patients.
复制标题
新诊断乳腺癌患者的健康相关健身与生活质量之间的关联。
DOI：
10.1007/s10549-023-06935-x
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发表时间：
2023
影响因子：
3.8
通讯作者：
Matth
中科院分区：
文献类型：
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作者：
Courneya,KerryS;An,Ki-Yong;Arthuso,FernandaZ;Bell,GordonJ;Morielli,AndriaR;McNeil,Jessica;Wang,Qinggang;Allen,SpencerJ;Ntoukas,StephanieM;McNeely,MargaretL;Vallance,JeffK;Culos-Reed,SNicole;Kopciuk,Karen;Yang,Lin;Matth
新诊断的乳腺癌患者面临着巨大的压力和不确定性，这可能会影响他们的生活质量（QoL）。本研究的目的是检查健康相关的健身（HRF）和生活质量之间的关联，在新诊断的乳腺癌患者从阿尔伯塔移动超越乳腺癌研究。方法新诊断的乳腺癌患者与早期疾病（n= 1458）在2012年和2019年之间在埃德蒙顿和卡尔加里招募，加拿大在诊断后90天内完成基线HRF和QoL评估。HRF评估包括心肺功能（VO 2峰值跑步机测试）、肌肉功能（上半身和下半身力量和耐力测试）和身体成分（双能X线吸收测定法）。通过医学结局研究简表36（SF-36）第2版评估QoL。我们使用逻辑回归分析来检验HRF的四分位数和较差/一般生活质量之间的关系结果在多变量分析中，最不适合的组与最适合的组相比，相对上身力量（OR = 3.19; 95%CI = 1.98-5.14）、瘦体重百分比（OR = 2.31; 95%CI = 1.37-3.89）和相对VO 2峰值（OR = 2.08; 95%CI = 1.21-3.57）独立地具有显著较高的不良/一般身体生活质量风险。没有发现有意义的协会为精神QoL.ConclusionsThe三个主要组成部分的HRF（肌肉健身，心肺健身，身体成分）独立与新诊断的乳腺癌患者的身体生活质量。旨在改善HRF这些组成部分的运动干预可以优化身体生活质量，并帮助新诊断的乳腺癌患者更好地为治疗和康复做好准备。
PurposeNewly diagnosed breast cancer patients face substantial stress and uncertainty that may undermine their quality of life (QoL). The purpose of the present study was to examine the associations between health-related fitness (HRF) and QoL in newly diagnosed breast cancer patients from the Alberta Moving Beyond Breast Cancer Study.MethodsNewly diagnosed breast cancer patients with early-stage disease (n= 1458) were recruited between 2012 and 2019 in Edmonton and Calgary, Canada to complete baseline HRF and QoL assessments within 90 days of diagnosis. HRF assessments included cardiorespiratory fitness (VO2peaktreadmill test), muscular fitness (upper and lower body strength and endurance tests), and body composition (dual x-ray absorptiometry). QoL was assessed by the Medical Outcomes Study Short Form 36 (SF-36) version 2. We used logistic regression analyses to examine the associations between quartiles of HRF and poor/fair QoL (bottom 20%) after adjusting for key covariates.ResultsIn multivariable analysis, the least fit groups compared to the most fit groups for relative upper body strength (OR = 3.19; 95% CI = 1.98–5.14), lean mass percentage (OR = 2.31; 95% CI = 1.37–3.89), and relative VO2peak(OR = 2.08; 95% CI = 1.21–3.57) were independently at a significantly higher risk of poor/fair physical QoL. No meaningful associations were found for mental QoL.ConclusionsThe three main components of HRF (muscular fitness, cardiorespiratory fitness, and body composition) were independently associated with physical QoL in newly diagnosed breast cancer patients. Exercise interventions designed to improve these components of HRF may optimize physical QoL and help newly diagnosed breast cancer patients better prepare for treatments and recovery.