Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders
Metabolic mapping of deep brain structures and associations with symptomatology in autism spectrum disorders
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DOI：
10.1016/j.rasd.2013.10.003
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发表时间：
2014-01-01
影响因子：
2.5
通讯作者：
Anagnostou, Evdokia
中科院分区：
文献类型：
--
作者：
Doyle-Thomas, Krissy A. R.;Card, Dallas;Anagnostou, Evdokia
自闭症的结构神经成像研究报告了与症状学有关的大脑深部结构中的非典型体积。关于这些区域的代谢变化，以及它们如何随着年龄和性别的变化，以及/或与临床行为的关系，人们知之甚少。用磁共振波谱技术测定了20例自闭症儿童和16例正常儿童(7-18岁)尾状核、壳核和丘脑中N-乙酰天冬氨酸、胆碱、肌酸、肌醇和谷氨酸的含量。与对照组相比，自闭症患者壳核中的谷氨酸/肌酸升高。此外，这两组人在该区域的谷氨酸水平都显示出与年龄相关的增加。与女孩相比，男孩丘脑中的胆碱/肌酸增加。最后，在ASD组中，三个区域的谷氨酸、胆碱和肌醇与行为评分之间存在相关性。这些发现表明，深部灰质神经化学发生了变化，这种变化对诊断、年龄和性别都很敏感，并与行为差异有关。(C)2013爱思唯尔有限公司。保留所有权利。
Structural neuroimaging studies in autism report atypical volume in deep brain structures which are related to symptomatology. Little is known about metabolic changes in these regions, and how they vary with age and sex, and/or relate to clinical behaviors. Using magnetic resonance spectroscopy we measured N-acetylaspartate, choline, creatine, myoinositol and glutamate in the caudate, putamen, and thalamus of 20 children with autism and 16 typically developing controls (7-18 years). Relative to controls, individuals with autism had elevated glutamate/creatine in the putamen. In addition, both groups showed age-related increases in glutamate in this region. Boys, relative to girls had increased choline/creatine in the thalamus. Lastly, there were correlations between glutamate, choline, and myoinositol in all three regions, and behavioral scores in the ASD group. These findings suggest changes in deep gray matter neurochemistry, which are sensitive to diagnosis, age and sex, and are associated with behavioral differences. (C) 2013 Elsevier Ltd. All rights reserved.